Factors affecting delivery of bile to the duodenum in man

J. R. Ashkin, D. T. Lyon, S. D. Shull, C. I. Wagner, R. D. Soloway

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Studies utilizing balloon-occludable T or duodenal tubes in subjects with and without gallbladders were undertaken to identify the contribution of the gallbladder, the sphincter of Oddi, and bile salts to the delivery of bile to the duodenum. Patients with and without a functional sphincter of Oddi and with and without a gallbladder were compared. The presence of a functional sphincter of Oddi in duodenal tube patients reduced bile salt output by more than 67% from that observed in T-tube patients. When cholecystectomized and normal patients were compared using the duodenal tube, peak bile salt output was significantly increased in normal subjects, reflecting gallbladder contraction, but total bile salt output was not significantly increased, suggesting that the gallbladder has a minor role in bile delivery. Exogenous infusion of cholecystokinin produced much more stable bile secretion than did endogenous release of cholecystokinin by intraduodenal infusion of essential amino acids. This rhythmic release of bile after endogenous cholecystokinin release was related to the concentration of bile salts in the intestinal lumen. Thus, delivery of bile to the duodenum is wave-like and is predominantly controlled by the sphincter of Oddi.

Original languageEnglish (US)
Pages (from-to)560-565
Number of pages6
JournalGastroenterology
Volume74
Issue number3
StatePublished - 1978
Externally publishedYes

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Sphincter of Oddi
Gallbladder
Bile Acids and Salts
Duodenum
Bile
Cholecystokinin
Essential Amino Acids

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Ashkin, J. R., Lyon, D. T., Shull, S. D., Wagner, C. I., & Soloway, R. D. (1978). Factors affecting delivery of bile to the duodenum in man. Gastroenterology, 74(3), 560-565.

Factors affecting delivery of bile to the duodenum in man. / Ashkin, J. R.; Lyon, D. T.; Shull, S. D.; Wagner, C. I.; Soloway, R. D.

In: Gastroenterology, Vol. 74, No. 3, 1978, p. 560-565.

Research output: Contribution to journalArticle

Ashkin, JR, Lyon, DT, Shull, SD, Wagner, CI & Soloway, RD 1978, 'Factors affecting delivery of bile to the duodenum in man', Gastroenterology, vol. 74, no. 3, pp. 560-565.
Ashkin JR, Lyon DT, Shull SD, Wagner CI, Soloway RD. Factors affecting delivery of bile to the duodenum in man. Gastroenterology. 1978;74(3):560-565.
Ashkin, J. R. ; Lyon, D. T. ; Shull, S. D. ; Wagner, C. I. ; Soloway, R. D. / Factors affecting delivery of bile to the duodenum in man. In: Gastroenterology. 1978 ; Vol. 74, No. 3. pp. 560-565.
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