TY - JOUR
T1 - Factors associated with endometrial cancer and hyperplasia among middle-aged and older Hispanics
AU - Rodriguez, Ana M.
AU - Polychronopoulou, Efstathia
AU - Hsu, Enshuo
AU - Shah, Rahul
AU - Lamiman, Kelly
AU - Kuo, Yong Fang
N1 - Funding Information:
The content is solely the responsibility of the authors and does not necessarily represent the official views of the Texas Resource Center on Minority Aging Research or the Cancer Prevention and Research Institute of Texas (CPRIT). This study was conducted with the support of the Texas Resource Center on Minority Aging Research (RCMAR) (Grant number 1P30AG059301–01) and CPRIT's Comparative Effectiveness Research on Cancer in Texas 2.0 (CERCIT Grant number RP160674 ). The sponsors had no role in the design, methods, data collection, analysis, interpretation of the data, preparation of this manuscript or in the decision to submit the paper for publications.
Funding Information:
The content is solely the responsibility of the authors and does not necessarily represent the official views of the Texas Resource Center on Minority Aging Research or the Cancer Prevention and Research Institute of Texas (CPRIT). This study was conducted with the support of the Texas Resource Center on Minority Aging Research (RCMAR) (Grant number 1P30AG059301?01) and CPRIT's Comparative Effectiveness Research on Cancer in Texas 2.0 (CERCIT Grant number RP160674). The sponsors had no role in the design, methods, data collection, analysis, interpretation of the data, preparation of this manuscript or in the decision to submit the paper for publications.
Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2021/1
Y1 - 2021/1
N2 - Objective: While disparities in endometrial hyperplasia and endometrial cancer are well documented in Blacks and Whites, limited information exists for Hispanics. The objective is to describe the patient characteristics associated with endometrial hyperplasia symptoms, endometrial hyperplasia with atypia and endometrial cancer, and assess factors contributing to racial/ethnic differences in disease outcomes. Methods: This single-center, retrospective study included women aged ≥50 years with ≥ two encounters for endometrial hyperplasia symptoms, endometrial hyperplasia with atypia and endometrial cancer between 2012 and 2016. Multivariate logistic regression models evaluated the predictors of endometrial cancer and hyperplasia. Results: We included 19,865 women (4749 endometrial hyperplasia symptoms, 71 endometrial hyperplasias with atypia, 201 endometrial cancers) with mean age of 60.45 years (SD 9.94). The odds of endometrial hyperplasia symptoms were higher in non-Hispanic Blacks (Odds Ratio [OR] 1.56, 95% Confidence Interval [CI] 1.20–1.72), Hispanics (OR 1.35, 95% CI 1.22–1.49), family history of female cancer (OR 1.25, 95% CI 1.12–1.39), hypertension (OR 1.24, 95% CI 1.14–1.35), and birth control use (OR 1.29, 95% CI 1.15–1.43). Odds of endometrial cancer and atypical hyperplasia increased for ages 60–64 (OR 7.95, 95% CI 3.26–19.37; OR 3.66, 95% 1.01–13.22) and being obese (OR 1.61, 95% CI 1.08–2.41; OR: 6.60, 95% CI 2.32–18.83). Odds of endometrial cancer increased with diabetes (OR 1.68, 95% CI 1.22–2.32). Conclusion(s): Patients with obesity and diabetes had increased odds of endometrial cancer and hyperplasia with atypia. Further study is needed to understand the exogenous estrogen effect contributing to the increased incidence among Hispanics.
AB - Objective: While disparities in endometrial hyperplasia and endometrial cancer are well documented in Blacks and Whites, limited information exists for Hispanics. The objective is to describe the patient characteristics associated with endometrial hyperplasia symptoms, endometrial hyperplasia with atypia and endometrial cancer, and assess factors contributing to racial/ethnic differences in disease outcomes. Methods: This single-center, retrospective study included women aged ≥50 years with ≥ two encounters for endometrial hyperplasia symptoms, endometrial hyperplasia with atypia and endometrial cancer between 2012 and 2016. Multivariate logistic regression models evaluated the predictors of endometrial cancer and hyperplasia. Results: We included 19,865 women (4749 endometrial hyperplasia symptoms, 71 endometrial hyperplasias with atypia, 201 endometrial cancers) with mean age of 60.45 years (SD 9.94). The odds of endometrial hyperplasia symptoms were higher in non-Hispanic Blacks (Odds Ratio [OR] 1.56, 95% Confidence Interval [CI] 1.20–1.72), Hispanics (OR 1.35, 95% CI 1.22–1.49), family history of female cancer (OR 1.25, 95% CI 1.12–1.39), hypertension (OR 1.24, 95% CI 1.14–1.35), and birth control use (OR 1.29, 95% CI 1.15–1.43). Odds of endometrial cancer and atypical hyperplasia increased for ages 60–64 (OR 7.95, 95% CI 3.26–19.37; OR 3.66, 95% 1.01–13.22) and being obese (OR 1.61, 95% CI 1.08–2.41; OR: 6.60, 95% CI 2.32–18.83). Odds of endometrial cancer increased with diabetes (OR 1.68, 95% CI 1.22–2.32). Conclusion(s): Patients with obesity and diabetes had increased odds of endometrial cancer and hyperplasia with atypia. Further study is needed to understand the exogenous estrogen effect contributing to the increased incidence among Hispanics.
KW - Endometrial cancer
KW - Endometrial hyperplasia with atypia
KW - Obesity-associated cancers
KW - Racial disparities
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U2 - 10.1016/j.ygyno.2020.10.033
DO - 10.1016/j.ygyno.2020.10.033
M3 - Article
C2 - 33221024
AN - SCOPUS:85096437794
SN - 0090-8258
VL - 160
SP - 16
EP - 23
JO - Gynecologic Oncology
JF - Gynecologic Oncology
IS - 1
ER -