Factors shaping the adaptive landscape for arboviruses

Implications for the emergence of disease

Lark L. Coffey, Naomi Forrester, Konstantin Tsetsarkin, Nikos Vasilakis, Scott Weaver

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Many examples of the emergence or re-emergence of infectious diseases involve the adaptation of zoonotic viruses to new amplification hosts or to humans themselves. These include several instances of simple mutational adaptations, often to hosts closely related to the natural reservoirs. However, based on theoretical grounds, arthropod-borne viruses, or arboviruses, may face several challenges for adaptation to new hosts. Here, we review recent findings regarding adaptive evolution of arboviruses and its impact on disease emergence. We focus on the zoonotic alphaviruses Venezuelan equine encephalitis and chikungunya viruses, which have undergone adaptive evolution that mediated recent outbreaks of disease, as well as the flaviviruses dengue and West Nile viruses, which have emerged via less dramatic adaptive mechanisms.

Original languageEnglish (US)
Pages (from-to)155-176
Number of pages22
JournalFuture Microbiology
Volume8
Issue number2
DOIs
StatePublished - Feb 2013

Fingerprint

Arboviruses
Zoonoses
Venezuelan Equine Encephalitis Viruses
Chikungunya virus
Alphavirus
Flavivirus
West Nile virus
Dengue
Disease Outbreaks
Communicable Diseases
Viruses

Keywords

  • adaptation
  • alphavirus
  • emergence
  • evolution
  • fitness
  • flavivirus
  • mosquito
  • vector

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Factors shaping the adaptive landscape for arboviruses : Implications for the emergence of disease. / Coffey, Lark L.; Forrester, Naomi; Tsetsarkin, Konstantin; Vasilakis, Nikos; Weaver, Scott.

In: Future Microbiology, Vol. 8, No. 2, 02.2013, p. 155-176.

Research output: Contribution to journalArticle

Coffey, Lark L. ; Forrester, Naomi ; Tsetsarkin, Konstantin ; Vasilakis, Nikos ; Weaver, Scott. / Factors shaping the adaptive landscape for arboviruses : Implications for the emergence of disease. In: Future Microbiology. 2013 ; Vol. 8, No. 2. pp. 155-176.
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