Factors that predict the presence of sentinel lymph node metastasis in patients with melanoma

Kelly M. McMasters, Sandra L. Wong, Michael J. Edwards, Merrick I. Ross, Celia Chao, R. Dirk Noyes, Vicki Viar, Patricia B. Cerrito, Douglas S. Reintgen

Research output: Contribution to journalArticle

133 Citations (Scopus)

Abstract

Background. This analysis was performed to identify prognostic factors that are predictive of sentinel lymph node (SLN) metastasis in melanoma. Methods. Analysis was performed of a multi-institutional, prospective, randomized trial of SLN biopsy for melanoma. Eligibility criteria included age 18 to 70 years, Breslow thickness of 1.0 mm or more, and clinically negative regional lymph nodes. SLNs were evaluated by serial sectioning and immunohistochemistry for S100. Univariate chi-square and multivariate logistic regression analyses were performed to assess factors predictive of the presence of a positive SLN. Probability values of less than .05 were considered significant. Results. SLNs were identified in 99.7% of patients. A total of 1058 patients were evaluated; 961 patients had complete data and were included in the statistical analysis. SLNs were positive for tumor in 208 of 961 patients (22%). Breslow thickness, Clark level, ulceration, and patient age were factors that were found to be independently predictive of the presence of SLN metastasis. Conclusions. Increasing Breslow thickness, Clark level of more than III, the presence of ulceration, and patient age of 60 years or less are the most important independent prognostic factors associated with the finding of positive SLN in patients with melanoma.

Original languageEnglish (US)
Pages (from-to)151-156
Number of pages6
JournalSurgery
Volume130
Issue number2
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Melanoma
Neoplasm Metastasis
Sentinel Lymph Node Biopsy
Age Factors
Sentinel Lymph Node
Logistic Models
Lymph Nodes
Immunohistochemistry
Regression Analysis
Neoplasms

ASJC Scopus subject areas

  • Surgery

Cite this

McMasters, K. M., Wong, S. L., Edwards, M. J., Ross, M. I., Chao, C., Noyes, R. D., ... Reintgen, D. S. (2001). Factors that predict the presence of sentinel lymph node metastasis in patients with melanoma. Surgery, 130(2), 151-156. https://doi.org/10.1067/msy.2001.115830

Factors that predict the presence of sentinel lymph node metastasis in patients with melanoma. / McMasters, Kelly M.; Wong, Sandra L.; Edwards, Michael J.; Ross, Merrick I.; Chao, Celia; Noyes, R. Dirk; Viar, Vicki; Cerrito, Patricia B.; Reintgen, Douglas S.

In: Surgery, Vol. 130, No. 2, 2001, p. 151-156.

Research output: Contribution to journalArticle

McMasters, KM, Wong, SL, Edwards, MJ, Ross, MI, Chao, C, Noyes, RD, Viar, V, Cerrito, PB & Reintgen, DS 2001, 'Factors that predict the presence of sentinel lymph node metastasis in patients with melanoma', Surgery, vol. 130, no. 2, pp. 151-156. https://doi.org/10.1067/msy.2001.115830
McMasters, Kelly M. ; Wong, Sandra L. ; Edwards, Michael J. ; Ross, Merrick I. ; Chao, Celia ; Noyes, R. Dirk ; Viar, Vicki ; Cerrito, Patricia B. ; Reintgen, Douglas S. / Factors that predict the presence of sentinel lymph node metastasis in patients with melanoma. In: Surgery. 2001 ; Vol. 130, No. 2. pp. 151-156.
@article{9c16e01123ee4057a2098212328378fe,
title = "Factors that predict the presence of sentinel lymph node metastasis in patients with melanoma",
abstract = "Background. This analysis was performed to identify prognostic factors that are predictive of sentinel lymph node (SLN) metastasis in melanoma. Methods. Analysis was performed of a multi-institutional, prospective, randomized trial of SLN biopsy for melanoma. Eligibility criteria included age 18 to 70 years, Breslow thickness of 1.0 mm or more, and clinically negative regional lymph nodes. SLNs were evaluated by serial sectioning and immunohistochemistry for S100. Univariate chi-square and multivariate logistic regression analyses were performed to assess factors predictive of the presence of a positive SLN. Probability values of less than .05 were considered significant. Results. SLNs were identified in 99.7{\%} of patients. A total of 1058 patients were evaluated; 961 patients had complete data and were included in the statistical analysis. SLNs were positive for tumor in 208 of 961 patients (22{\%}). Breslow thickness, Clark level, ulceration, and patient age were factors that were found to be independently predictive of the presence of SLN metastasis. Conclusions. Increasing Breslow thickness, Clark level of more than III, the presence of ulceration, and patient age of 60 years or less are the most important independent prognostic factors associated with the finding of positive SLN in patients with melanoma.",
author = "McMasters, {Kelly M.} and Wong, {Sandra L.} and Edwards, {Michael J.} and Ross, {Merrick I.} and Celia Chao and Noyes, {R. Dirk} and Vicki Viar and Cerrito, {Patricia B.} and Reintgen, {Douglas S.}",
year = "2001",
doi = "10.1067/msy.2001.115830",
language = "English (US)",
volume = "130",
pages = "151--156",
journal = "Surgery",
issn = "0039-6060",
publisher = "Mosby Inc.",
number = "2",

}

TY - JOUR

T1 - Factors that predict the presence of sentinel lymph node metastasis in patients with melanoma

AU - McMasters, Kelly M.

AU - Wong, Sandra L.

AU - Edwards, Michael J.

AU - Ross, Merrick I.

AU - Chao, Celia

AU - Noyes, R. Dirk

AU - Viar, Vicki

AU - Cerrito, Patricia B.

AU - Reintgen, Douglas S.

PY - 2001

Y1 - 2001

N2 - Background. This analysis was performed to identify prognostic factors that are predictive of sentinel lymph node (SLN) metastasis in melanoma. Methods. Analysis was performed of a multi-institutional, prospective, randomized trial of SLN biopsy for melanoma. Eligibility criteria included age 18 to 70 years, Breslow thickness of 1.0 mm or more, and clinically negative regional lymph nodes. SLNs were evaluated by serial sectioning and immunohistochemistry for S100. Univariate chi-square and multivariate logistic regression analyses were performed to assess factors predictive of the presence of a positive SLN. Probability values of less than .05 were considered significant. Results. SLNs were identified in 99.7% of patients. A total of 1058 patients were evaluated; 961 patients had complete data and were included in the statistical analysis. SLNs were positive for tumor in 208 of 961 patients (22%). Breslow thickness, Clark level, ulceration, and patient age were factors that were found to be independently predictive of the presence of SLN metastasis. Conclusions. Increasing Breslow thickness, Clark level of more than III, the presence of ulceration, and patient age of 60 years or less are the most important independent prognostic factors associated with the finding of positive SLN in patients with melanoma.

AB - Background. This analysis was performed to identify prognostic factors that are predictive of sentinel lymph node (SLN) metastasis in melanoma. Methods. Analysis was performed of a multi-institutional, prospective, randomized trial of SLN biopsy for melanoma. Eligibility criteria included age 18 to 70 years, Breslow thickness of 1.0 mm or more, and clinically negative regional lymph nodes. SLNs were evaluated by serial sectioning and immunohistochemistry for S100. Univariate chi-square and multivariate logistic regression analyses were performed to assess factors predictive of the presence of a positive SLN. Probability values of less than .05 were considered significant. Results. SLNs were identified in 99.7% of patients. A total of 1058 patients were evaluated; 961 patients had complete data and were included in the statistical analysis. SLNs were positive for tumor in 208 of 961 patients (22%). Breslow thickness, Clark level, ulceration, and patient age were factors that were found to be independently predictive of the presence of SLN metastasis. Conclusions. Increasing Breslow thickness, Clark level of more than III, the presence of ulceration, and patient age of 60 years or less are the most important independent prognostic factors associated with the finding of positive SLN in patients with melanoma.

UR - http://www.scopus.com/inward/record.url?scp=0034906910&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034906910&partnerID=8YFLogxK

U2 - 10.1067/msy.2001.115830

DO - 10.1067/msy.2001.115830

M3 - Article

C2 - 11490343

AN - SCOPUS:0034906910

VL - 130

SP - 151

EP - 156

JO - Surgery

JF - Surgery

SN - 0039-6060

IS - 2

ER -