Failure of TPN supplementation to improve liver function, immunity, and mortality in thermally injured patients

David Herndon, M. D. Stein, T. C. Rutan, S. Abston, H. Linares

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

Hypermetabolism with negative nitrogen balance and immune deficiencies characterize the systemic response to major thermal injury. Patients with burns >50% of the total body surface area (TBSA) initially have poor gastrointestinal function, making it difficult to deliver sufficient enteral calories to meet nutritional requirements. Controversy has developed over whether to supplement oral alimentation with total parenteral nutrition (TPN) early in their treatment. This study randomly assigned 28 patients with burns >50% TBSA to receive TPN supplementation or no TPN supplementation in the first 10 days postburn. Patients receiving TPN supplementation had significantly lower T-cell helper-to-suppressor cell ratios than the unsupplemented group. However, there was no difference in mortality between the groups (eight in each). All patients who died developed hepatomegaly associated with fatty infiltration cholestasis and antemortem liver function abnormalities, indicating that this syndrome is the result of burn injury itself, not TPN.

Original languageEnglish (US)
Pages (from-to)195-204
Number of pages10
JournalJournal of Trauma
Volume27
Issue number2
StatePublished - 1987

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Total Parenteral Nutrition
Immunity
Mortality
Liver
Body Surface Area
Burns
Nutritional Requirements
Hepatomegaly
Cholestasis
Wounds and Injuries
Helper-Inducer T-Lymphocytes
Small Intestine
Nitrogen
Hot Temperature

ASJC Scopus subject areas

  • Surgery

Cite this

Herndon, D., Stein, M. D., Rutan, T. C., Abston, S., & Linares, H. (1987). Failure of TPN supplementation to improve liver function, immunity, and mortality in thermally injured patients. Journal of Trauma, 27(2), 195-204.

Failure of TPN supplementation to improve liver function, immunity, and mortality in thermally injured patients. / Herndon, David; Stein, M. D.; Rutan, T. C.; Abston, S.; Linares, H.

In: Journal of Trauma, Vol. 27, No. 2, 1987, p. 195-204.

Research output: Contribution to journalArticle

Herndon, D, Stein, MD, Rutan, TC, Abston, S & Linares, H 1987, 'Failure of TPN supplementation to improve liver function, immunity, and mortality in thermally injured patients', Journal of Trauma, vol. 27, no. 2, pp. 195-204.
Herndon, David ; Stein, M. D. ; Rutan, T. C. ; Abston, S. ; Linares, H. / Failure of TPN supplementation to improve liver function, immunity, and mortality in thermally injured patients. In: Journal of Trauma. 1987 ; Vol. 27, No. 2. pp. 195-204.
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