Fat distribution and insulin resistance in young adult nonobese Asian Indian women

Magdalene Szuszkiewicz-Garcia, Rong Li, Scott M. Grundy, Nicola Abate, Manisha Chandalia

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Although Asian Indian (people of Indian subcontinent descent) men are shown to have higher total and truncal body fat as well as greater insulin resistance compared to white men matched for total body fat and age, data in women are not conclusive. The objective of this study was to compare total and regional fat distribution and insulin sensitivity between healthy young premenopausal Asian Indian and white women of similar body mass index (BMI). Twenty Asian Indian women (65% immigrants and 35% first generation living in Dallas) and 31 white women of similar age and BMI [age 24±3 vs. 25±4; BMI 22±4 vs. 23±5; mean±standard deviation (SD) in Asian Indian and white, respectively] without diabetes were evaluated with anthropometric measurements, underwater weighing for percentage of total body fat mass, magnetic resonance imaging of whole abdomen for measurement of abdominal subcutaneous and intraperitoneal fat mass, and euglycemic-hyperinsulinemic clamp study for measurement of insulin sensitivity. There were no differences in waist or hip circumference, total body subcutaneous abdominal or intraperitoneal fat mass, fasting plasma glucose, and insulin levels between Asian Indian women and white women. The peripheral glucose disposal rate (Rd) during hyperinsulinemic- euglycemic clamp was found to be almost identical in the two study groups (median value of 6.9 and 6.8 mg/min per kg of body weight, for Asian Indians and whites, respectively). For similar total or regional fat content, the glucose disposal rate was comparable in the two study groups. In conclusion, we demonstrate that young Asian Indian women do not have excess abdominal or intraperitoneal fat or insulin resistance for similar BMI compared to white women of European descent.

Original languageEnglish (US)
Pages (from-to)326-330
Number of pages5
JournalMetabolic Syndrome and Related Disorders
Volume10
Issue number5
DOIs
StatePublished - Oct 1 2012

Fingerprint

Insulin Resistance
Young Adult
Fats
Body Mass Index
Adipose Tissue
Glucose Clamp Technique
Glucose
Abdominal Subcutaneous Fat
Abdomen
Hip
Fasting
Body Weight
Magnetic Resonance Imaging
Insulin

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Fat distribution and insulin resistance in young adult nonobese Asian Indian women. / Szuszkiewicz-Garcia, Magdalene; Li, Rong; Grundy, Scott M.; Abate, Nicola; Chandalia, Manisha.

In: Metabolic Syndrome and Related Disorders, Vol. 10, No. 5, 01.10.2012, p. 326-330.

Research output: Contribution to journalArticle

Szuszkiewicz-Garcia, M, Li, R, Grundy, SM, Abate, N & Chandalia, M 2012, 'Fat distribution and insulin resistance in young adult nonobese Asian Indian women', Metabolic Syndrome and Related Disorders, vol. 10, no. 5, pp. 326-330. https://doi.org/10.1089/met.2012.0041
Szuszkiewicz-Garcia, Magdalene ; Li, Rong ; Grundy, Scott M. ; Abate, Nicola ; Chandalia, Manisha. / Fat distribution and insulin resistance in young adult nonobese Asian Indian women. In: Metabolic Syndrome and Related Disorders. 2012 ; Vol. 10, No. 5. pp. 326-330.
@article{e39a807762be446b8b658c2f0b8bc1fb,
title = "Fat distribution and insulin resistance in young adult nonobese Asian Indian women",
abstract = "Although Asian Indian (people of Indian subcontinent descent) men are shown to have higher total and truncal body fat as well as greater insulin resistance compared to white men matched for total body fat and age, data in women are not conclusive. The objective of this study was to compare total and regional fat distribution and insulin sensitivity between healthy young premenopausal Asian Indian and white women of similar body mass index (BMI). Twenty Asian Indian women (65{\%} immigrants and 35{\%} first generation living in Dallas) and 31 white women of similar age and BMI [age 24±3 vs. 25±4; BMI 22±4 vs. 23±5; mean±standard deviation (SD) in Asian Indian and white, respectively] without diabetes were evaluated with anthropometric measurements, underwater weighing for percentage of total body fat mass, magnetic resonance imaging of whole abdomen for measurement of abdominal subcutaneous and intraperitoneal fat mass, and euglycemic-hyperinsulinemic clamp study for measurement of insulin sensitivity. There were no differences in waist or hip circumference, total body subcutaneous abdominal or intraperitoneal fat mass, fasting plasma glucose, and insulin levels between Asian Indian women and white women. The peripheral glucose disposal rate (Rd) during hyperinsulinemic- euglycemic clamp was found to be almost identical in the two study groups (median value of 6.9 and 6.8 mg/min per kg of body weight, for Asian Indians and whites, respectively). For similar total or regional fat content, the glucose disposal rate was comparable in the two study groups. In conclusion, we demonstrate that young Asian Indian women do not have excess abdominal or intraperitoneal fat or insulin resistance for similar BMI compared to white women of European descent.",
author = "Magdalene Szuszkiewicz-Garcia and Rong Li and Grundy, {Scott M.} and Nicola Abate and Manisha Chandalia",
year = "2012",
month = "10",
day = "1",
doi = "10.1089/met.2012.0041",
language = "English (US)",
volume = "10",
pages = "326--330",
journal = "Metabolic Syndrome and Related Disorders",
issn = "1540-4196",
publisher = "Mary Ann Liebert Inc.",
number = "5",

}

TY - JOUR

T1 - Fat distribution and insulin resistance in young adult nonobese Asian Indian women

AU - Szuszkiewicz-Garcia, Magdalene

AU - Li, Rong

AU - Grundy, Scott M.

AU - Abate, Nicola

AU - Chandalia, Manisha

PY - 2012/10/1

Y1 - 2012/10/1

N2 - Although Asian Indian (people of Indian subcontinent descent) men are shown to have higher total and truncal body fat as well as greater insulin resistance compared to white men matched for total body fat and age, data in women are not conclusive. The objective of this study was to compare total and regional fat distribution and insulin sensitivity between healthy young premenopausal Asian Indian and white women of similar body mass index (BMI). Twenty Asian Indian women (65% immigrants and 35% first generation living in Dallas) and 31 white women of similar age and BMI [age 24±3 vs. 25±4; BMI 22±4 vs. 23±5; mean±standard deviation (SD) in Asian Indian and white, respectively] without diabetes were evaluated with anthropometric measurements, underwater weighing for percentage of total body fat mass, magnetic resonance imaging of whole abdomen for measurement of abdominal subcutaneous and intraperitoneal fat mass, and euglycemic-hyperinsulinemic clamp study for measurement of insulin sensitivity. There were no differences in waist or hip circumference, total body subcutaneous abdominal or intraperitoneal fat mass, fasting plasma glucose, and insulin levels between Asian Indian women and white women. The peripheral glucose disposal rate (Rd) during hyperinsulinemic- euglycemic clamp was found to be almost identical in the two study groups (median value of 6.9 and 6.8 mg/min per kg of body weight, for Asian Indians and whites, respectively). For similar total or regional fat content, the glucose disposal rate was comparable in the two study groups. In conclusion, we demonstrate that young Asian Indian women do not have excess abdominal or intraperitoneal fat or insulin resistance for similar BMI compared to white women of European descent.

AB - Although Asian Indian (people of Indian subcontinent descent) men are shown to have higher total and truncal body fat as well as greater insulin resistance compared to white men matched for total body fat and age, data in women are not conclusive. The objective of this study was to compare total and regional fat distribution and insulin sensitivity between healthy young premenopausal Asian Indian and white women of similar body mass index (BMI). Twenty Asian Indian women (65% immigrants and 35% first generation living in Dallas) and 31 white women of similar age and BMI [age 24±3 vs. 25±4; BMI 22±4 vs. 23±5; mean±standard deviation (SD) in Asian Indian and white, respectively] without diabetes were evaluated with anthropometric measurements, underwater weighing for percentage of total body fat mass, magnetic resonance imaging of whole abdomen for measurement of abdominal subcutaneous and intraperitoneal fat mass, and euglycemic-hyperinsulinemic clamp study for measurement of insulin sensitivity. There were no differences in waist or hip circumference, total body subcutaneous abdominal or intraperitoneal fat mass, fasting plasma glucose, and insulin levels between Asian Indian women and white women. The peripheral glucose disposal rate (Rd) during hyperinsulinemic- euglycemic clamp was found to be almost identical in the two study groups (median value of 6.9 and 6.8 mg/min per kg of body weight, for Asian Indians and whites, respectively). For similar total or regional fat content, the glucose disposal rate was comparable in the two study groups. In conclusion, we demonstrate that young Asian Indian women do not have excess abdominal or intraperitoneal fat or insulin resistance for similar BMI compared to white women of European descent.

UR - http://www.scopus.com/inward/record.url?scp=84872836965&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872836965&partnerID=8YFLogxK

U2 - 10.1089/met.2012.0041

DO - 10.1089/met.2012.0041

M3 - Article

VL - 10

SP - 326

EP - 330

JO - Metabolic Syndrome and Related Disorders

JF - Metabolic Syndrome and Related Disorders

SN - 1540-4196

IS - 5

ER -