Fat preference: A novel model of eating behavior in rats

James M. Kasper, Sarah B. Johnson, Jonathan D. Hommel

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Obesity is a growing problem in the United States of America, with more than a third of the population classified as obese. One factor contributing to this multifactorial disorder is the consumption of a high fat diet, a behavior that has been shown to increase both caloric intake and body fat content. However, the elements regulating preference for high fat food over other foods remain understudied. To overcome this deficit, a model to quickly and easily test changes in the preference for dietary fat was developed. The Fat Preference model presents rats with a series of choices between foods with differing fat content. Like humans, rats have a natural bias toward consuming high fat food, making the rat model ideal for translational studies. Changes in preference can be ascribed to the effect of either genetic differences or pharmacological interventions. This model allows for the exploration of determinates of fat preference and screening pharmacotherapeutic agents that influence acquisition of obesity.

Original languageEnglish (US)
Article numbere51575
JournalJournal of Visualized Experiments
Issue number88
StatePublished - Jun 27 2014


  • Animal model
  • Behavior
  • Choice
  • Diet
  • Fat
  • Issue 88
  • Macronutrient
  • Obesity
  • Preference

ASJC Scopus subject areas

  • General Neuroscience
  • General Chemical Engineering
  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology


Dive into the research topics of 'Fat preference: A novel model of eating behavior in rats'. Together they form a unique fingerprint.

Cite this