Fatal neonatal echovirus 6 infection: Autopsy case report and review of the literature

K. C. Ventura, H. Hawkins, M. B. Smith, David Walker

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

A full-term, healthy male neonate was delivered by caesarian section to a 26-year-old primigravida woman who had a history of fever and upper respiratory tract infection. On the fourth day of life, the neonate developed a sepsis-like syndrome, acute respiratory and renal failure, and disseminated intravascular coagulopathy. He died 13 days after birth. Postmortem examination revealed jaundice, anasarca, massive hepatic necrosis, adrenal hemorrhagic necrosis, renal medullary hemorrhage, hemorrhagic noninflammatory pneumonia, and severe encephalomalacia. Echovirus type 6 was isolated from blood, liver, and lungs. Although uncommon, echovirus type 6 infection may produce a spectrum of pathologic findings similar to those seen with the more commonly virulent echovirus type 11.

Original languageEnglish (US)
Pages (from-to)85-90
Number of pages6
JournalModern Pathology
Volume14
Issue number2
DOIs
StatePublished - 2001

Fingerprint

Human echovirus 6
Echovirus Infections
Kidney Papillary Necrosis
Autopsy
Massive Hepatic Necrosis
Encephalomalacia
Newborn Infant
Human Enterovirus B
Systemic Inflammatory Response Syndrome
Jaundice
Acute Kidney Injury
Cesarean Section
Respiratory Tract Infections
Respiratory Insufficiency
Edema
Pneumonia
Fever
Parturition
Hemorrhage
Lung

Keywords

  • Echovirus 6
  • Hepatoadrenal necrosis
  • Neonatal infection

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Fatal neonatal echovirus 6 infection : Autopsy case report and review of the literature. / Ventura, K. C.; Hawkins, H.; Smith, M. B.; Walker, David.

In: Modern Pathology, Vol. 14, No. 2, 2001, p. 85-90.

Research output: Contribution to journalArticle

Ventura, K. C. ; Hawkins, H. ; Smith, M. B. ; Walker, David. / Fatal neonatal echovirus 6 infection : Autopsy case report and review of the literature. In: Modern Pathology. 2001 ; Vol. 14, No. 2. pp. 85-90.
@article{7d6a9e5cb4c84e3388880fe48b82d49f,
title = "Fatal neonatal echovirus 6 infection: Autopsy case report and review of the literature",
abstract = "A full-term, healthy male neonate was delivered by caesarian section to a 26-year-old primigravida woman who had a history of fever and upper respiratory tract infection. On the fourth day of life, the neonate developed a sepsis-like syndrome, acute respiratory and renal failure, and disseminated intravascular coagulopathy. He died 13 days after birth. Postmortem examination revealed jaundice, anasarca, massive hepatic necrosis, adrenal hemorrhagic necrosis, renal medullary hemorrhage, hemorrhagic noninflammatory pneumonia, and severe encephalomalacia. Echovirus type 6 was isolated from blood, liver, and lungs. Although uncommon, echovirus type 6 infection may produce a spectrum of pathologic findings similar to those seen with the more commonly virulent echovirus type 11.",
keywords = "Echovirus 6, Hepatoadrenal necrosis, Neonatal infection",
author = "Ventura, {K. C.} and H. Hawkins and Smith, {M. B.} and David Walker",
year = "2001",
doi = "10.1038/modpathol.3880260",
language = "English (US)",
volume = "14",
pages = "85--90",
journal = "Modern Pathology",
issn = "0893-3952",
publisher = "Nature Publishing Group",
number = "2",

}

TY - JOUR

T1 - Fatal neonatal echovirus 6 infection

T2 - Autopsy case report and review of the literature

AU - Ventura, K. C.

AU - Hawkins, H.

AU - Smith, M. B.

AU - Walker, David

PY - 2001

Y1 - 2001

N2 - A full-term, healthy male neonate was delivered by caesarian section to a 26-year-old primigravida woman who had a history of fever and upper respiratory tract infection. On the fourth day of life, the neonate developed a sepsis-like syndrome, acute respiratory and renal failure, and disseminated intravascular coagulopathy. He died 13 days after birth. Postmortem examination revealed jaundice, anasarca, massive hepatic necrosis, adrenal hemorrhagic necrosis, renal medullary hemorrhage, hemorrhagic noninflammatory pneumonia, and severe encephalomalacia. Echovirus type 6 was isolated from blood, liver, and lungs. Although uncommon, echovirus type 6 infection may produce a spectrum of pathologic findings similar to those seen with the more commonly virulent echovirus type 11.

AB - A full-term, healthy male neonate was delivered by caesarian section to a 26-year-old primigravida woman who had a history of fever and upper respiratory tract infection. On the fourth day of life, the neonate developed a sepsis-like syndrome, acute respiratory and renal failure, and disseminated intravascular coagulopathy. He died 13 days after birth. Postmortem examination revealed jaundice, anasarca, massive hepatic necrosis, adrenal hemorrhagic necrosis, renal medullary hemorrhage, hemorrhagic noninflammatory pneumonia, and severe encephalomalacia. Echovirus type 6 was isolated from blood, liver, and lungs. Although uncommon, echovirus type 6 infection may produce a spectrum of pathologic findings similar to those seen with the more commonly virulent echovirus type 11.

KW - Echovirus 6

KW - Hepatoadrenal necrosis

KW - Neonatal infection

UR - http://www.scopus.com/inward/record.url?scp=0035108106&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035108106&partnerID=8YFLogxK

U2 - 10.1038/modpathol.3880260

DO - 10.1038/modpathol.3880260

M3 - Article

C2 - 11235909

AN - SCOPUS:0035108106

VL - 14

SP - 85

EP - 90

JO - Modern Pathology

JF - Modern Pathology

SN - 0893-3952

IS - 2

ER -