Fatal nontraumatic splenic rupture in hemophilia and the Kasabach Merritt syndrome

C. Stout, J. W. Hampton, J. D. Anderson, N. Oruc

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Fatal nontraumatic splenic rupture is documented in two adult patients, one with classical hemophilia and the other with the Kasabach Merritt syndrome. Splenic rupture was due to multiple hemangioma like lesions in both patients. These lesions apparently were acquired, possibly as a result of infection and disordered coagulation. The mechanism of rupture of the lesions could not be determined. The rarity of nontraumatic splenic rupture in these two syndromes probably explains why splenectomy was not done in either patient even though, in retrospect, evidence for subcapsular splenic hemorrhage was present for 2 and 17 days before death from rupture of the splenic capsule, respectively. Although splenectomy is more hazardous in patients with impaired coagulation, the situation is also more urgent in such patients since exsanguination occurs so rapidly following splenic capsular rupture (20 min and 90 min, respectively, in the present two patients). Patients with impaired coagulation who develop evidence of subcapsular splenic hemorrhage should be evaluated quickly and definitively, using splenic angiography if appropriate. Once subcapsular splenic hemorrhage has been confirmed, splenectomy should be seriously considered.

Original languageEnglish (US)
Pages (from-to)791-795
Number of pages5
JournalSouthern Medical Journal
Volume66
Issue number7
StatePublished - 1973

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Kasabach-Merritt Syndrome
Splenic Rupture
Hemophilia A
Splenectomy
Hemorrhage
Exsanguination
Hemangioma
Capsules
Rupture
Angiography

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Stout, C., Hampton, J. W., Anderson, J. D., & Oruc, N. (1973). Fatal nontraumatic splenic rupture in hemophilia and the Kasabach Merritt syndrome. Southern Medical Journal, 66(7), 791-795.

Fatal nontraumatic splenic rupture in hemophilia and the Kasabach Merritt syndrome. / Stout, C.; Hampton, J. W.; Anderson, J. D.; Oruc, N.

In: Southern Medical Journal, Vol. 66, No. 7, 1973, p. 791-795.

Research output: Contribution to journalArticle

Stout, C, Hampton, JW, Anderson, JD & Oruc, N 1973, 'Fatal nontraumatic splenic rupture in hemophilia and the Kasabach Merritt syndrome', Southern Medical Journal, vol. 66, no. 7, pp. 791-795.
Stout, C. ; Hampton, J. W. ; Anderson, J. D. ; Oruc, N. / Fatal nontraumatic splenic rupture in hemophilia and the Kasabach Merritt syndrome. In: Southern Medical Journal. 1973 ; Vol. 66, No. 7. pp. 791-795.
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