Fatal reactive hemophagocytosis related to disseminated histoplasmosis with endocarditis

An unusual case diagnosed at autopsy

Zhiqin Wang, Alexander Duarte, Vicki J. Schnadig

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Reactive hemophagocytic syndrome (RHS) is an uncommon life-threatening disorder. It is believed to be caused by widespread non-neoplastic proliferation and inappropriate activation of mature macrophages, resulting in excessive cytokine activation which leads to hematophagocytosis by cells of the macrophage-monocyte lineage and multiorgan dysfunction. RHS may be associated with infections caused by bacterial, viral and fungal organisms as well as lymphoproliferative disorders, nonhematopoietic malignancies, autoimmune diseases and some therapeutic drugs. Immunosuppression is a frequent underlying condition in RHS. The following case presentation describes a patient with a history of chronic hepatitis C, cryoglobulinemia, renal failure and Staphylococcus aureus perinephric abscess and bacteremia, who, at autopsy, was found to have disseminated histoplasmosis with fungal endocarditis and RHS.

Original languageEnglish (US)
Pages (from-to)208-211
Number of pages4
JournalSouthern Medical Journal
Volume100
Issue number2
DOIs
StatePublished - Feb 2007

Fingerprint

Hemophagocytic Lymphohistiocytosis
Histoplasmosis
Endocarditis
Autopsy
Cryoglobulinemia
Lymphoproliferative Disorders
Macrophage Activation
Mycoses
Chronic Hepatitis C
Bacteremia
Bacterial Infections
Immunosuppression
Abscess
Autoimmune Diseases
Renal Insufficiency
Staphylococcus aureus
Monocytes
Macrophages
Cytokines
Pharmaceutical Preparations

Keywords

  • Autopsy
  • Disseminated histoplasmosis
  • Fungal endocarditis
  • Reactive hemophagocytic syndrome

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Fatal reactive hemophagocytosis related to disseminated histoplasmosis with endocarditis : An unusual case diagnosed at autopsy. / Wang, Zhiqin; Duarte, Alexander; Schnadig, Vicki J.

In: Southern Medical Journal, Vol. 100, No. 2, 02.2007, p. 208-211.

Research output: Contribution to journalArticle

@article{b5946634face49359a13145d756e1bdb,
title = "Fatal reactive hemophagocytosis related to disseminated histoplasmosis with endocarditis: An unusual case diagnosed at autopsy",
abstract = "Reactive hemophagocytic syndrome (RHS) is an uncommon life-threatening disorder. It is believed to be caused by widespread non-neoplastic proliferation and inappropriate activation of mature macrophages, resulting in excessive cytokine activation which leads to hematophagocytosis by cells of the macrophage-monocyte lineage and multiorgan dysfunction. RHS may be associated with infections caused by bacterial, viral and fungal organisms as well as lymphoproliferative disorders, nonhematopoietic malignancies, autoimmune diseases and some therapeutic drugs. Immunosuppression is a frequent underlying condition in RHS. The following case presentation describes a patient with a history of chronic hepatitis C, cryoglobulinemia, renal failure and Staphylococcus aureus perinephric abscess and bacteremia, who, at autopsy, was found to have disseminated histoplasmosis with fungal endocarditis and RHS.",
keywords = "Autopsy, Disseminated histoplasmosis, Fungal endocarditis, Reactive hemophagocytic syndrome",
author = "Zhiqin Wang and Alexander Duarte and Schnadig, {Vicki J.}",
year = "2007",
month = "2",
doi = "10.1097/SMJ.0b013e31802b2812",
language = "English (US)",
volume = "100",
pages = "208--211",
journal = "Southern Medical Journal",
issn = "0038-4348",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Fatal reactive hemophagocytosis related to disseminated histoplasmosis with endocarditis

T2 - An unusual case diagnosed at autopsy

AU - Wang, Zhiqin

AU - Duarte, Alexander

AU - Schnadig, Vicki J.

PY - 2007/2

Y1 - 2007/2

N2 - Reactive hemophagocytic syndrome (RHS) is an uncommon life-threatening disorder. It is believed to be caused by widespread non-neoplastic proliferation and inappropriate activation of mature macrophages, resulting in excessive cytokine activation which leads to hematophagocytosis by cells of the macrophage-monocyte lineage and multiorgan dysfunction. RHS may be associated with infections caused by bacterial, viral and fungal organisms as well as lymphoproliferative disorders, nonhematopoietic malignancies, autoimmune diseases and some therapeutic drugs. Immunosuppression is a frequent underlying condition in RHS. The following case presentation describes a patient with a history of chronic hepatitis C, cryoglobulinemia, renal failure and Staphylococcus aureus perinephric abscess and bacteremia, who, at autopsy, was found to have disseminated histoplasmosis with fungal endocarditis and RHS.

AB - Reactive hemophagocytic syndrome (RHS) is an uncommon life-threatening disorder. It is believed to be caused by widespread non-neoplastic proliferation and inappropriate activation of mature macrophages, resulting in excessive cytokine activation which leads to hematophagocytosis by cells of the macrophage-monocyte lineage and multiorgan dysfunction. RHS may be associated with infections caused by bacterial, viral and fungal organisms as well as lymphoproliferative disorders, nonhematopoietic malignancies, autoimmune diseases and some therapeutic drugs. Immunosuppression is a frequent underlying condition in RHS. The following case presentation describes a patient with a history of chronic hepatitis C, cryoglobulinemia, renal failure and Staphylococcus aureus perinephric abscess and bacteremia, who, at autopsy, was found to have disseminated histoplasmosis with fungal endocarditis and RHS.

KW - Autopsy

KW - Disseminated histoplasmosis

KW - Fungal endocarditis

KW - Reactive hemophagocytic syndrome

UR - http://www.scopus.com/inward/record.url?scp=33846811381&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846811381&partnerID=8YFLogxK

U2 - 10.1097/SMJ.0b013e31802b2812

DO - 10.1097/SMJ.0b013e31802b2812

M3 - Article

VL - 100

SP - 208

EP - 211

JO - Southern Medical Journal

JF - Southern Medical Journal

SN - 0038-4348

IS - 2

ER -