Fatal reactive hemophagocytosis related to disseminated histoplasmosis with endocarditis: An unusual case diagnosed at autopsy

Zhiqin Wang, Alexander G. Duarte, Vicki J. Schnadig

Research output: Contribution to journalArticle

18 Scopus citations


Reactive hemophagocytic syndrome (RHS) is an uncommon life-threatening disorder. It is believed to be caused by widespread non-neoplastic proliferation and inappropriate activation of mature macrophages, resulting in excessive cytokine activation which leads to hematophagocytosis by cells of the macrophage-monocyte lineage and multiorgan dysfunction. RHS may be associated with infections caused by bacterial, viral and fungal organisms as well as lymphoproliferative disorders, nonhematopoietic malignancies, autoimmune diseases and some therapeutic drugs. Immunosuppression is a frequent underlying condition in RHS. The following case presentation describes a patient with a history of chronic hepatitis C, cryoglobulinemia, renal failure and Staphylococcus aureus perinephric abscess and bacteremia, who, at autopsy, was found to have disseminated histoplasmosis with fungal endocarditis and RHS.

Original languageEnglish (US)
Pages (from-to)208-211
Number of pages4
JournalSouthern medical journal
Issue number2
StatePublished - Feb 1 2007



  • Autopsy
  • Disseminated histoplasmosis
  • Fungal endocarditis
  • Reactive hemophagocytic syndrome

ASJC Scopus subject areas

  • Medicine(all)

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