Fatal rocky mountain spotted fever in a 2-year-old child

David H. Walker, Christopher D. Paddock

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


A 2-year-old boy developed an acute undifferentiated febrile disease that was considered clinically to be a nonspecific viral syndrome. Progressive deterioration with severe central nervous system involvement, cerebral edema, and brain stem herniation led to death 8 days after onset. Disseminated rickettsial infection of endothelium was accompanied by a lymphohistiocytic vasculitis that is usually the hallmark microscopic lesion recognized by the pathologist. The diagnosis was established by immunohistochemical demonstration of intraendothelial spotted fever group rickettsiae.

Original languageEnglish (US)
Pages (from-to)238-241
Number of pages4
JournalPathology Case Reviews
Issue number6
StatePublished - Nov 2011


  • Rickettsiae
  • Rocky Mountain spotted fever
  • vasculitis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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