Fatal Spotted Fever Rickettsiosis, Minas Gerais, Brazil

Márcio Antonio Moreira Galvão, J. Stephen Dumler, Cláudio Lísias Mafra, Simone Berger Calic, Chequer Buffe Chamone, Gracco Cesarino Filho, Juan Pablo Olano, David H. Walker

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


The emergence and reemergence of a serious infectious disease are often associated with a high case-fatality rate because of misdiagnosis and inappropriate or delayed treatment. The current reemergence of spotted fever rickettsiosis caused by Rickettsia rickettsii in Brazil has resulted in a high proportion of fatal cases. We describe two familial clusters of Brazilian spotted fever in the state of Minas Gerais, involving six children 9 months to 15 years of age; five died. Immunohistochemical investigation of tissues obtained at necropsy of a child in each location, Novo Cruzeiro and Coronel Fabriciano municipalities, established the diagnosis by demonstration of disseminated endothelial infection with spotted fever group rickettsiae. The diagnosis in the two fatal cases from Coronel Fabriciano and the surviving patient from Novo Cruzeiro was further supported by immunofluorescence serologic tests.

Original languageEnglish (US)
Pages (from-to)1402-1405
Number of pages4
JournalEmerging infectious diseases
Issue number11
StatePublished - Nov 2003

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases


Dive into the research topics of 'Fatal Spotted Fever Rickettsiosis, Minas Gerais, Brazil'. Together they form a unique fingerprint.

Cite this