Fatal Spotted Fever Rickettsiosis, Minas Gerais, Brazil

Márcio Antonio Moreira Galvão, J. Stephen Dumler, Cláudio Lísias Mafra, Simone Berger Calic, Chequer Buffe Chamone, Gracco Cesarino Filho, Juan Olano, David Walker

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The emergence and reemergence of a serious infectious disease are often associated with a high case-fatality rate because of misdiagnosis and inappropriate or delayed treatment. The current reemergence of spotted fever rickettsiosis caused by Rickettsia rickettsii in Brazil has resulted in a high proportion of fatal cases. We describe two familial clusters of Brazilian spotted fever in the state of Minas Gerais, involving six children 9 months to 15 years of age; five died. Immunohistochemical investigation of tissues obtained at necropsy of a child in each location, Novo Cruzeiro and Coronel Fabriciano municipalities, established the diagnosis by demonstration of disseminated endothelial infection with spotted fever group rickettsiae. The diagnosis in the two fatal cases from Coronel Fabriciano and the surviving patient from Novo Cruzeiro was further supported by immunofluorescence serologic tests.

Original languageEnglish (US)
Pages (from-to)1402-1405
Number of pages4
JournalEmerging Infectious Diseases
Volume9
Issue number11
StatePublished - Nov 2003

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Brazil
Fever
Rickettsia rickettsii
Rickettsia
Serologic Tests
Diagnostic Errors
Fluorescent Antibody Technique
Communicable Diseases
Mortality
Infection
Therapeutics

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Moreira Galvão, M. A., Dumler, J. S., Mafra, C. L., Calic, S. B., Chamone, C. B., Filho, G. C., ... Walker, D. (2003). Fatal Spotted Fever Rickettsiosis, Minas Gerais, Brazil. Emerging Infectious Diseases, 9(11), 1402-1405.

Fatal Spotted Fever Rickettsiosis, Minas Gerais, Brazil. / Moreira Galvão, Márcio Antonio; Dumler, J. Stephen; Mafra, Cláudio Lísias; Calic, Simone Berger; Chamone, Chequer Buffe; Filho, Gracco Cesarino; Olano, Juan; Walker, David.

In: Emerging Infectious Diseases, Vol. 9, No. 11, 11.2003, p. 1402-1405.

Research output: Contribution to journalArticle

Moreira Galvão, MA, Dumler, JS, Mafra, CL, Calic, SB, Chamone, CB, Filho, GC, Olano, J & Walker, D 2003, 'Fatal Spotted Fever Rickettsiosis, Minas Gerais, Brazil', Emerging Infectious Diseases, vol. 9, no. 11, pp. 1402-1405.
Moreira Galvão MA, Dumler JS, Mafra CL, Calic SB, Chamone CB, Filho GC et al. Fatal Spotted Fever Rickettsiosis, Minas Gerais, Brazil. Emerging Infectious Diseases. 2003 Nov;9(11):1402-1405.
Moreira Galvão, Márcio Antonio ; Dumler, J. Stephen ; Mafra, Cláudio Lísias ; Calic, Simone Berger ; Chamone, Chequer Buffe ; Filho, Gracco Cesarino ; Olano, Juan ; Walker, David. / Fatal Spotted Fever Rickettsiosis, Minas Gerais, Brazil. In: Emerging Infectious Diseases. 2003 ; Vol. 9, No. 11. pp. 1402-1405.
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