TY - JOUR
T1 - Fatty acid ethyl esters
T2 - Non-oxidative metabolites of ethanol
AU - Laposata, M.
AU - Szczepiorkowski, Z. M.
AU - Brown, J. E.
N1 - Funding Information:
This work was supported by Grants DK37454 and DK43159 from the National Institutes of Health.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1995
Y1 - 1995
N2 - Fatty acid ethyl esters are esterification products of fatty acids and ethanol. These compounds have been detected in the serum and cells of individuals following ethanol ingestion. Fatty acid ethyl esters can be quantitated by gas chromatography-mass spectroscopy (GC-MS) in the serum following ethanol ingestion and have been found in concentrations up to 42 μM. Fatty acid ethyl esters have also been isolated from adipose tissue of subjects ingesting fatty acid ethyl ester capsules as well as from subjects ingesting ethanol. HepG2 cells, a human hepatoblastoma cell line, have also been shown to generate fatty acid ethyl esters when incubated with 1.25 μM fatty acid and 0.17 M ethanol. Fatty acid ethyl esters were found to be toxic to HepG2 cells when presented to the cells in the core of low density lipoprotein particles.
AB - Fatty acid ethyl esters are esterification products of fatty acids and ethanol. These compounds have been detected in the serum and cells of individuals following ethanol ingestion. Fatty acid ethyl esters can be quantitated by gas chromatography-mass spectroscopy (GC-MS) in the serum following ethanol ingestion and have been found in concentrations up to 42 μM. Fatty acid ethyl esters have also been isolated from adipose tissue of subjects ingesting fatty acid ethyl ester capsules as well as from subjects ingesting ethanol. HepG2 cells, a human hepatoblastoma cell line, have also been shown to generate fatty acid ethyl esters when incubated with 1.25 μM fatty acid and 0.17 M ethanol. Fatty acid ethyl esters were found to be toxic to HepG2 cells when presented to the cells in the core of low density lipoprotein particles.
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U2 - 10.1016/0952-3278(95)90003-9
DO - 10.1016/0952-3278(95)90003-9
M3 - Article
C2 - 7784463
AN - SCOPUS:0028876859
SN - 0952-3278
VL - 52
SP - 87
EP - 91
JO - Prostaglandins, Leukotrienes and Essential Fatty Acids
JF - Prostaglandins, Leukotrienes and Essential Fatty Acids
IS - 2-3
ER -