Fatty acid ethyl esters

Recent observations

Michael Laposata, Ali Hasaba, Catherine A. Best, Danita M. Yoerger, Brendan M. McQuillan, Raneem O. Salem, Majed A. Refaai, Britt L. Soderberg

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Fatty acid ethyl esters (FAEE), esterification products of fatty acids and ethanol, have been shown to be mediators of ethanol-induced cell injury and their presence in the blood and tissues is a marker of ethanol intake. Recently, it has been shown that FAEE are produced within seconds of infusion of ethanol into the heart, when using a protocol similar to that used for myocardial ablation. This raises the possibility that the mechanism for the death of myocytes in cardiac ablation involves the generation of toxic FAEE. It has also been recently demonstrated that chronic alcoholics have a high concentration of a specific FAEE species - ethyl oleate. The use of the serum ethyl oleate concentration may be helpful in differentiating binge drinkers from chronic alcoholics.

Original languageEnglish (US)
Pages (from-to)193-196
Number of pages4
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume67
Issue number2-3
DOIs
StatePublished - Aug 2002
Externally publishedYes

Fingerprint

Esters
Fatty Acids
Ethanol
Alcoholics
Ablation
Esterification
Poisons
Cardiac Myocytes
Blood
Tissue
Wounds and Injuries
Serum
ethyl oleate

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Laposata, M., Hasaba, A., Best, C. A., Yoerger, D. M., McQuillan, B. M., Salem, R. O., ... Soderberg, B. L. (2002). Fatty acid ethyl esters: Recent observations. Prostaglandins Leukotrienes and Essential Fatty Acids, 67(2-3), 193-196. https://doi.org/10.1054/plef.2002.0418

Fatty acid ethyl esters : Recent observations. / Laposata, Michael; Hasaba, Ali; Best, Catherine A.; Yoerger, Danita M.; McQuillan, Brendan M.; Salem, Raneem O.; Refaai, Majed A.; Soderberg, Britt L.

In: Prostaglandins Leukotrienes and Essential Fatty Acids, Vol. 67, No. 2-3, 08.2002, p. 193-196.

Research output: Contribution to journalArticle

Laposata, M, Hasaba, A, Best, CA, Yoerger, DM, McQuillan, BM, Salem, RO, Refaai, MA & Soderberg, BL 2002, 'Fatty acid ethyl esters: Recent observations', Prostaglandins Leukotrienes and Essential Fatty Acids, vol. 67, no. 2-3, pp. 193-196. https://doi.org/10.1054/plef.2002.0418
Laposata, Michael ; Hasaba, Ali ; Best, Catherine A. ; Yoerger, Danita M. ; McQuillan, Brendan M. ; Salem, Raneem O. ; Refaai, Majed A. ; Soderberg, Britt L. / Fatty acid ethyl esters : Recent observations. In: Prostaglandins Leukotrienes and Essential Fatty Acids. 2002 ; Vol. 67, No. 2-3. pp. 193-196.
@article{0a1fcc7338214e2f8bd98c22ca728070,
title = "Fatty acid ethyl esters: Recent observations",
abstract = "Fatty acid ethyl esters (FAEE), esterification products of fatty acids and ethanol, have been shown to be mediators of ethanol-induced cell injury and their presence in the blood and tissues is a marker of ethanol intake. Recently, it has been shown that FAEE are produced within seconds of infusion of ethanol into the heart, when using a protocol similar to that used for myocardial ablation. This raises the possibility that the mechanism for the death of myocytes in cardiac ablation involves the generation of toxic FAEE. It has also been recently demonstrated that chronic alcoholics have a high concentration of a specific FAEE species - ethyl oleate. The use of the serum ethyl oleate concentration may be helpful in differentiating binge drinkers from chronic alcoholics.",
author = "Michael Laposata and Ali Hasaba and Best, {Catherine A.} and Yoerger, {Danita M.} and McQuillan, {Brendan M.} and Salem, {Raneem O.} and Refaai, {Majed A.} and Soderberg, {Britt L.}",
year = "2002",
month = "8",
doi = "10.1054/plef.2002.0418",
language = "English (US)",
volume = "67",
pages = "193--196",
journal = "Prostaglandins Leukotrienes and Essential Fatty Acids",
issn = "0952-3278",
publisher = "Churchill Livingstone",
number = "2-3",

}

TY - JOUR

T1 - Fatty acid ethyl esters

T2 - Recent observations

AU - Laposata, Michael

AU - Hasaba, Ali

AU - Best, Catherine A.

AU - Yoerger, Danita M.

AU - McQuillan, Brendan M.

AU - Salem, Raneem O.

AU - Refaai, Majed A.

AU - Soderberg, Britt L.

PY - 2002/8

Y1 - 2002/8

N2 - Fatty acid ethyl esters (FAEE), esterification products of fatty acids and ethanol, have been shown to be mediators of ethanol-induced cell injury and their presence in the blood and tissues is a marker of ethanol intake. Recently, it has been shown that FAEE are produced within seconds of infusion of ethanol into the heart, when using a protocol similar to that used for myocardial ablation. This raises the possibility that the mechanism for the death of myocytes in cardiac ablation involves the generation of toxic FAEE. It has also been recently demonstrated that chronic alcoholics have a high concentration of a specific FAEE species - ethyl oleate. The use of the serum ethyl oleate concentration may be helpful in differentiating binge drinkers from chronic alcoholics.

AB - Fatty acid ethyl esters (FAEE), esterification products of fatty acids and ethanol, have been shown to be mediators of ethanol-induced cell injury and their presence in the blood and tissues is a marker of ethanol intake. Recently, it has been shown that FAEE are produced within seconds of infusion of ethanol into the heart, when using a protocol similar to that used for myocardial ablation. This raises the possibility that the mechanism for the death of myocytes in cardiac ablation involves the generation of toxic FAEE. It has also been recently demonstrated that chronic alcoholics have a high concentration of a specific FAEE species - ethyl oleate. The use of the serum ethyl oleate concentration may be helpful in differentiating binge drinkers from chronic alcoholics.

UR - http://www.scopus.com/inward/record.url?scp=0036694386&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036694386&partnerID=8YFLogxK

U2 - 10.1054/plef.2002.0418

DO - 10.1054/plef.2002.0418

M3 - Article

VL - 67

SP - 193

EP - 196

JO - Prostaglandins Leukotrienes and Essential Fatty Acids

JF - Prostaglandins Leukotrienes and Essential Fatty Acids

SN - 0952-3278

IS - 2-3

ER -