Fatty acid ethyl esters

toxic non-oxidative metabolites of ethanol and markers of ethanol intake.

Catherine A. Best, Michael Laposata

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

This report describes the biochemistry of fatty acid ethyl esters (FAEE), non-oxidative metabolites of ethanol, and their clinical significance. We review information regarding the enzymes responsible for FAEE synthesis and degradation, and the mechanisms involved with the intracellular and extracellular transport of FAEE and FAEE-mediated cytotoxicity. Also a summary of reports on the emerging clinical significance and diagnostic utility of FAEE as short and long-term markers of alcohol consumption, and the methodological aspects of FAEE assessment is included.

Original languageEnglish (US)
JournalFrontiers in bioscience : a journal and virtual library
Volume8
StatePublished - 2003
Externally publishedYes

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Poisons
Metabolites
Esters
Ethanol
Fatty Acids
Biochemistry
Cytotoxicity
Alcohol Drinking
Alcohols
Degradation
Enzymes

Cite this

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abstract = "This report describes the biochemistry of fatty acid ethyl esters (FAEE), non-oxidative metabolites of ethanol, and their clinical significance. We review information regarding the enzymes responsible for FAEE synthesis and degradation, and the mechanisms involved with the intracellular and extracellular transport of FAEE and FAEE-mediated cytotoxicity. Also a summary of reports on the emerging clinical significance and diagnostic utility of FAEE as short and long-term markers of alcohol consumption, and the methodological aspects of FAEE assessment is included.",
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