Fatty acid ethyl esters: Toxic non-oxidative metabolites of ethanol and markers of ethanol intake

Catherine A. Best, Michael Laposata

Research output: Contribution to journalReview article

37 Scopus citations

Abstract

This report describes the biochemistry of fatty acid ethyl esters (FAEE), non-oxidative metabolites of ethanol, and their clinical significance. We review information regarding the enzymes responsible for FAEE synthesis and degradation, and the mechanisms involved with the intracellular and extracellular transport of FAEE and FAEE-mediated cytotoxicity. Also a summary of reports on the emerging clinical significance and diagnostic utility of FAEE as short and long-term markers of alcohol consumption, and the methodological aspects of FAEE assessment is included.

Original languageEnglish (US)
Pages (from-to)e203-e218
JournalFrontiers in Bioscience
Volume8
StatePublished - Dec 1 2003
Externally publishedYes

Keywords

  • Alcohol
  • Biomarker
  • Ethanol
  • FAEE
  • Fatty Acid Ethyl Esters
  • Review

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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