FDA Approval of the First-Ever PROTAC: Vepdegestrant (ARV-471) Marks a New Era in Targeted Protein Degradation

Anil Kumar; Saghir Ali; Qiang Shen; Jia Zhou

doi:10.1021/acs.jmedchem.6c02076

FDA Approval of the First-Ever PROTAC: Vepdegestrant (ARV-471) Marks a New Era in Targeted Protein Degradation

Anil Kumar
, Saghir Ali
, Qiang Shen
, Jia Zhou

Pharmacology & Toxicology

Research output: Contribution to journal › Editorial › peer-review

2 Scopus citations

Original language	English (US)
Pages (from-to)	16135-16142
Number of pages	8
Journal	Journal of medicinal chemistry
Volume	69
Issue number	14
DOIs	https://doi.org/10.1021/acs.jmedchem.6c02076
State	Published - Jul 23 2026

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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10.1021/acs.jmedchem.6c02076

Cite this

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title = "FDA Approval of the First-Ever PROTAC: Vepdegestrant (ARV-471) Marks a New Era in Targeted Protein Degradation",

author = "Anil Kumar and Saghir Ali and Qiang Shen and Jia Zhou",

year = "2026",

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day = "23",

doi = "10.1021/acs.jmedchem.6c02076",

language = "English (US)",

volume = "69",

pages = "16135--16142",

journal = "Journal of medicinal chemistry",

issn = "0022-2623",

publisher = "American Chemical Society",

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T1 - FDA Approval of the First-Ever PROTAC

T2 - Vepdegestrant (ARV-471) Marks a New Era in Targeted Protein Degradation

AU - Kumar, Anil

AU - Ali, Saghir

AU - Shen, Qiang

AU - Zhou, Jia

PY - 2026/7/23

Y1 - 2026/7/23

UR - https://www.scopus.com/pages/publications/105045648439

UR - https://www.scopus.com/pages/publications/105045648439#tab=citedBy

U2 - 10.1021/acs.jmedchem.6c02076

DO - 10.1021/acs.jmedchem.6c02076

M3 - Editorial

C2 - 42489504

AN - SCOPUS:105045648439

SN - 0022-2623

VL - 69

SP - 16135

EP - 16142

JO - Journal of medicinal chemistry

JF - Journal of medicinal chemistry

IS - 14

ER -

FDA Approval of the First-Ever PROTAC: Vepdegestrant (ARV-471) Marks a New Era in Targeted Protein Degradation

ASJC Scopus subject areas

Access to Document

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