Abstract
IgM and IgG antibodies to the SARS-CoV-2 virus are detected in subjects who have recovered from COVID-19; IgM antibodies persist in a 1/3 of infected subjects up to 12 months from the moment of the disease, while IgG antibodies are present in the vast majority of cases (97%; medium and high levels antibodies were registered in 85% of cases). By the 12th month, 40% of those who recovered still have a very high level of IgG antibodies to the S-protein (>500 BAU/ml). In the feces, urine, and blood serum of patients with long-term persistent IgM antibodies, no coronavirus antigens were detected. After vaccination with the Gam-COVID-Vac vaccine, IgG antibodies to the S-protein are detected in 100% of cases and remain at a high level for 4 months, by the 5-6th month, the level of antibodies decreases. During revaccination, the level of IgG antibodies to S-protein reaches high values earlier than during primary vaccination, and remains high for 4 months (observation period). The blood sera of recovered and vaccinated patients have a high virus-neutralizing activity (at least 1:80), while its level is somewhat higher in recovered patients.
Original language | English (US) |
---|---|
Pages (from-to) | 734-739 |
Number of pages | 6 |
Journal | Bulletin of Experimental Biology and Medicine |
Volume | 173 |
Issue number | 6 |
DOIs | |
State | Published - Oct 2022 |
Externally published | Yes |
Keywords
- antibody levels
- COVID-19
- Gam-COVID-Vac
- humoral immunity
- SARS-CoV-2
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology