Fetal and neonatal alloimmune thrombocytopenia

A management algorithm based on risk stratification

Luis Pacheco, Richard L. Berkowitz, Kenneth J. Moise, James B. Bussel, Janice G. McFarland, George Saade

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Fetal and neonatal alloimmune thrombocytopenia constitutes the most common cause of severe thrombocytopenia in fetuses and neonates and of intracranial hemorrhage among term newborns. The cornerstone of therapy involves the use of steroids and intravenous immunoglobulins. Despite the risk of potentially devastating consequences to the fetus, fetal blood sampling has typically been used to document response to therapy. We propose a therapeutic algorithm based on risk stratification with individualized treatment optimization without the use of fetal blood sampling.

Original languageEnglish (US)
Pages (from-to)1157-1163
Number of pages7
JournalObstetrics and Gynecology
Volume118
Issue number5
DOIs
StatePublished - Nov 2011

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Neonatal Alloimmune Thrombocytopenia
Fetal Blood
Fetus
Intracranial Hemorrhages
Intravenous Immunoglobulins
Thrombocytopenia
Therapeutics
Steroids

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Fetal and neonatal alloimmune thrombocytopenia : A management algorithm based on risk stratification. / Pacheco, Luis; Berkowitz, Richard L.; Moise, Kenneth J.; Bussel, James B.; McFarland, Janice G.; Saade, George.

In: Obstetrics and Gynecology, Vol. 118, No. 5, 11.2011, p. 1157-1163.

Research output: Contribution to journalArticle

Pacheco, Luis ; Berkowitz, Richard L. ; Moise, Kenneth J. ; Bussel, James B. ; McFarland, Janice G. ; Saade, George. / Fetal and neonatal alloimmune thrombocytopenia : A management algorithm based on risk stratification. In: Obstetrics and Gynecology. 2011 ; Vol. 118, No. 5. pp. 1157-1163.
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