Fetal and neonatal alloimmune thrombocytopenia: A management algorithm based on risk stratification

Luis D. Pacheco, Richard L. Berkowitz, Kenneth J. Moise, James B. Bussel, Janice G. McFarland, George R. Saade

Research output: Contribution to journalReview article

60 Scopus citations

Abstract

Fetal and neonatal alloimmune thrombocytopenia constitutes the most common cause of severe thrombocytopenia in fetuses and neonates and of intracranial hemorrhage among term newborns. The cornerstone of therapy involves the use of steroids and intravenous immunoglobulins. Despite the risk of potentially devastating consequences to the fetus, fetal blood sampling has typically been used to document response to therapy. We propose a therapeutic algorithm based on risk stratification with individualized treatment optimization without the use of fetal blood sampling.

Original languageEnglish (US)
Pages (from-to)1157-1163
Number of pages7
JournalObstetrics and gynecology
Volume118
Issue number5
DOIs
StatePublished - Nov 1 2011

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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