Fetal drug therapy

Erik Rytting, Jennifer Waltz, Mahmoud Ahmed

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Maternal illness, infection, or disease may require medication during pregnancy, which presents the challenge of balancing the benefits and risks associated with fetal drug exposure. In cases of certain fetal disorders, however, the opposite situation arises: the need to weigh the benefits of fetal drug therapy against the risks of maternal side effects. Fetal arrhythmias, lung maturation, hematological or endocrine disorders, and other conditions may warrant drug delivery to the fetus. This chapter presents advantages and disadvantages of several strategies for fetal drug delivery, such as direct fetal injection. An overview of human placental transport functions is provided as it relates to fetal therapy following maternal drug administration. Potential applications of gene therapy, stem cell transplantation, and nanomedicine are highlighted and special considerations for fetal pharmacokinetics and ethics are discussed.

Original languageEnglish (US)
Title of host publicationClinical Pharmacology During Pregnancy
PublisherElsevier
Pages61-78
Number of pages18
ISBN (Electronic)9780128189023
DOIs
StatePublished - Jan 1 2021

Keywords

  • Fetal disease
  • Fetal therapy
  • Pharmacology
  • Placenta
  • Pregnancy

ASJC Scopus subject areas

  • General Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

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