Fetal membrane architecture, aging and inflammation in pregnancy and parturition

Ramkumar Menon; Lauren S. Richardson; Martha Lappas

doi:10.1016/j.placenta.2018.11.003

Fetal membrane architecture, aging and inflammation in pregnancy and parturition

Ramkumar Menon, Lauren S. Richardson, Martha Lappas

Obstetrics & Gynecology

Research output: Contribution to journal › Review article › peer-review

108 Scopus citations

Abstract

Preterm birth is the single major cause of infant mortality. Short and long term outcomes for infants are often worse in cases of preterm premature rupture of the fetal membranes (pPROM). Thus, increased knowledge of the structure characteristics of fetal membranes as well as the mechanisms of membrane rupture are essential if we are to develop effective treatment strategies to prevent pPROM. In this review, we focus on the role of inflammation and senescence in fetal membrane biology.

Original language	English (US)
Pages (from-to)	40-45
Number of pages	6
Journal	Placenta
Volume	79
DOIs	https://doi.org/10.1016/j.placenta.2018.11.003
State	Published - Apr 2019

Keywords

Fetal membranes
Inflammation
Senescence
Structure

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology
Developmental Biology

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10.1016/j.placenta.2018.11.003

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title = "Fetal membrane architecture, aging and inflammation in pregnancy and parturition",

abstract = "Preterm birth is the single major cause of infant mortality. Short and long term outcomes for infants are often worse in cases of preterm premature rupture of the fetal membranes (pPROM). Thus, increased knowledge of the structure characteristics of fetal membranes as well as the mechanisms of membrane rupture are essential if we are to develop effective treatment strategies to prevent pPROM. In this review, we focus on the role of inflammation and senescence in fetal membrane biology.",

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AU - Menon, Ramkumar

AU - Richardson, Lauren S.

AU - Lappas, Martha

PY - 2019/4

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N2 - Preterm birth is the single major cause of infant mortality. Short and long term outcomes for infants are often worse in cases of preterm premature rupture of the fetal membranes (pPROM). Thus, increased knowledge of the structure characteristics of fetal membranes as well as the mechanisms of membrane rupture are essential if we are to develop effective treatment strategies to prevent pPROM. In this review, we focus on the role of inflammation and senescence in fetal membrane biology.

AB - Preterm birth is the single major cause of infant mortality. Short and long term outcomes for infants are often worse in cases of preterm premature rupture of the fetal membranes (pPROM). Thus, increased knowledge of the structure characteristics of fetal membranes as well as the mechanisms of membrane rupture are essential if we are to develop effective treatment strategies to prevent pPROM. In this review, we focus on the role of inflammation and senescence in fetal membrane biology.

KW - Fetal membranes

KW - Inflammation

KW - Senescence

KW - Structure

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DO - 10.1016/j.placenta.2018.11.003

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VL - 79

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JO - Placenta

JF - Placenta

ER -

Fetal membrane architecture, aging and inflammation in pregnancy and parturition

Abstract

Keywords

ASJC Scopus subject areas

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