Fetal Membranes, Not a Mere Appendage of the Placenta, but a Critical Part of the Fetal-Maternal Interface Controlling Parturition

Research output: Contribution to journalReview article


Fetal membranes (FMs) play a role in pregnancy maintenance and promoting parturition at term. The FMs are not just part of the placenta, structurally or functionally. Although attached to the placenta, the amnion has a separate embryologic origin, and the chorion deviates from the placenta by the first month of pregnancy. Other than immune protection, these FM functions are not those of the placenta. FM dysfunction is associated with and may cause adverse pregnancy outcomes. Ongoing research may identify biomarkers for pending preterm premature rupture of the FMs as well as therapeutic agents, to prevent it and resulting preterm birth.

Original languageEnglish (US)
Pages (from-to)147-162
Number of pages16
JournalObstetrics and gynecology clinics of North America
Issue number1
StatePublished - Mar 2020



  • Aging
  • Amniochorion
  • GM-CSF
  • Oxidative stress
  • pPROM
  • Preterm birth
  • Senescence

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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