Fetal sex-related dysregulation in testosterone production and their receptor expression in the human placenta with preeclampsia

K. Sathishkumar, M. Balakrishnan, V. Chinnathambi, M. Chauhan, G. D.V. Hankins, C. Yallampalli

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Objective: To determine the effects of fetal sex on aromatase and androgen receptor (AR) expression in the placenta of normal and preeclamptic pregnancies. Study Design: Placentae from preeclamptic (five female and six male fetuses) and healthy pregnancies (seven female and seven male fetuses) were examined by immunofluorescence, western blotting and quantitative reverse transcriptase PCR. Result: Placental AR levels were significantly higher (P < 0.05) in placentae of both male and female fetuses compared with their respective sexes in normal pregnancies. The placental aromatase levels varied depending on fetal sex. If the fetus was female, aromatase levels were substantially higher (P < 0.05) in preeclamptic than in normal placentae. If the fetus was male, the aromatase levels were significantly lower (P < 0.05) in preeclamptic than in normal placentae. Placental aromatase levels were significantly higher (P < 0.05) in male- than in female-bearing normal placentae. Conclusion: Dysregulation in androgen production and signaling in preeclamptic placentae may contribute to placental abnormalities, increasing the frequency of maternal-fetal complications associated with preeclampsia.

Original languageEnglish (US)
Pages (from-to)328-335
Number of pages8
JournalJournal of Perinatology
Volume32
Issue number5
DOIs
StatePublished - May 1 2012

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Keywords

  • androgen receptor
  • aromatase
  • fetal sex
  • placenta
  • preeclampsia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Sathishkumar, K., Balakrishnan, M., Chinnathambi, V., Chauhan, M., Hankins, G. D. V., & Yallampalli, C. (2012). Fetal sex-related dysregulation in testosterone production and their receptor expression in the human placenta with preeclampsia. Journal of Perinatology, 32(5), 328-335. https://doi.org/10.1038/jp.2011.101