Fever from the forest: Prospects for the continued emergence of sylvatic dengue virus and its impact on public health

Nikos Vasilakis, Jane Cardosa, Kathryn A. Hanley, Edward C. Holmes, Scott C. Weaver

Research output: Contribution to journalReview articlepeer-review

173 Scopus citations

Abstract

The four dengue virus (DENV) serotypes that circulate among humans emerged independently from ancestral sylvatic progenitors that were present in non-human primates, following the establishment of human populations that were large and dense enough to support continuous inter-human transmission by mosquitoes. This ancestral sylvatic-DENV transmission cycle still exists and is maintained in non-human primates and Aedes mosquitoes in the forests of Southeast Asia and West Africa. Here, we provide an overview of the ecology and molecular evolution of sylvatic DENV and its potential for adaptation to human transmission. We also emphasize how the study of sylvatic DENV will improve our ability to understand, predict and, ideally, avert further DENV emergence.

Original languageEnglish (US)
Pages (from-to)532-541
Number of pages10
JournalNature Reviews Microbiology
Volume9
Issue number7
DOIs
StatePublished - May 2011

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Microbiology(all)
  • Infectious Diseases

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