TY - GEN
T1 - Fiber-optic probes for biomedical optoacoustic imaging, monitoring, and sensing
AU - Esenaliev, Rinat
N1 - Funding Information:
Grant support: NIH grants #R01EB00763 and #U54EB007954 from the National Institute of Biomedical Imaging and Bioengineering, #R01NS044345 and #R21NS40531 from the National Institute of Neurological Disorders and Stroke, #R41HD076568, #R43HD075551, and #R41HD094542 from the Eunice Kennedy Shriver National Institute of Child Health & Human Development, and #R41HL10309501 from the National Heart, Lung and Blood Institute, the Texas Emerging Technology Fund, and the Moody Center for Brain and Spinal Cord Injury
Publisher Copyright:
© COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.
PY - 2019
Y1 - 2019
N2 - We proposed biomedical optoacoustics/photoacoustics more than 25 years ago and developed this technology for imaging, monitoring, and sensing applications [1-35]. Optoacoustic diagnostic modality is based on thermoelastic generation of optoacoustic waves and combines high optical contrast and ultrasound spatial resolution. We developed optoacoustic systems (including highly-compact, multi-wavelength, fibercoupled, FDA-compliant laser diode systems) with fiber-optic, ultra-sensitive, wide-band optoacoustic probes. We tested them in small and large animal studies and in clinical studies in healthy volunteers and patients with traumatic brain injury and circulatory shock as well as in neonatal and fetal patients. The high sensitivity and bandwidth of the fiber-optic optoacoustic probes allowed for: 1) signal detection from tissues at depths well beyond the optical diffusion limit (up to several centimeters); 2) detection of microscopic tissue volumes; 3) optoacoustic imaging in large tissue phantoms and tissues with high resolution; 4) monitoring of tissue thermotherapy; 5) noninvasive probing of cerebral tissues in large animals and in humans (both neonates and adults); 6) accurate oxygenation measurements in humans in tissues and in specific blood vessels; and 7) optoacoustic waves therapeutic effects that can be used for noninvasive optoacoustic theranostics. The obtained data indicated that the systems were capable of optoacoustic measurements and mapping of cerebral blood oxygenation in adults and in neonates, detection of intracranial hematomas, oxygenation measurements both from cerebral and central blood vessels and from cerebral tissues.
AB - We proposed biomedical optoacoustics/photoacoustics more than 25 years ago and developed this technology for imaging, monitoring, and sensing applications [1-35]. Optoacoustic diagnostic modality is based on thermoelastic generation of optoacoustic waves and combines high optical contrast and ultrasound spatial resolution. We developed optoacoustic systems (including highly-compact, multi-wavelength, fibercoupled, FDA-compliant laser diode systems) with fiber-optic, ultra-sensitive, wide-band optoacoustic probes. We tested them in small and large animal studies and in clinical studies in healthy volunteers and patients with traumatic brain injury and circulatory shock as well as in neonatal and fetal patients. The high sensitivity and bandwidth of the fiber-optic optoacoustic probes allowed for: 1) signal detection from tissues at depths well beyond the optical diffusion limit (up to several centimeters); 2) detection of microscopic tissue volumes; 3) optoacoustic imaging in large tissue phantoms and tissues with high resolution; 4) monitoring of tissue thermotherapy; 5) noninvasive probing of cerebral tissues in large animals and in humans (both neonates and adults); 6) accurate oxygenation measurements in humans in tissues and in specific blood vessels; and 7) optoacoustic waves therapeutic effects that can be used for noninvasive optoacoustic theranostics. The obtained data indicated that the systems were capable of optoacoustic measurements and mapping of cerebral blood oxygenation in adults and in neonates, detection of intracranial hematomas, oxygenation measurements both from cerebral and central blood vessels and from cerebral tissues.
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U2 - 10.1117/12.2539195
DO - 10.1117/12.2539195
M3 - Conference contribution
AN - SCOPUS:85073384666
T3 - Proceedings of SPIE - The International Society for Optical Engineering
BT - Seventh European Workshop on Optical Fibre Sensors
A2 - Kalli, Kyriacos
A2 - Brambilla, Gilberto
A2 - O'Keeffe, Sinead
PB - SPIE
T2 - 7th European Workshop on Optical Fibre Sensors, EWOFS 2019
Y2 - 1 October 2019 through 4 October 2019
ER -