Fiber-optic probes for biomedical optoacoustic imaging, monitoring, and sensing

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    We proposed biomedical optoacoustics/photoacoustics more than 25 years ago and developed this technology for imaging, monitoring, and sensing applications [1-35]. Optoacoustic diagnostic modality is based on thermoelastic generation of optoacoustic waves and combines high optical contrast and ultrasound spatial resolution. We developed optoacoustic systems (including highly-compact, multi-wavelength, fibercoupled, FDA-compliant laser diode systems) with fiber-optic, ultra-sensitive, wide-band optoacoustic probes. We tested them in small and large animal studies and in clinical studies in healthy volunteers and patients with traumatic brain injury and circulatory shock as well as in neonatal and fetal patients. The high sensitivity and bandwidth of the fiber-optic optoacoustic probes allowed for: 1) signal detection from tissues at depths well beyond the optical diffusion limit (up to several centimeters); 2) detection of microscopic tissue volumes; 3) optoacoustic imaging in large tissue phantoms and tissues with high resolution; 4) monitoring of tissue thermotherapy; 5) noninvasive probing of cerebral tissues in large animals and in humans (both neonates and adults); 6) accurate oxygenation measurements in humans in tissues and in specific blood vessels; and 7) optoacoustic waves therapeutic effects that can be used for noninvasive optoacoustic theranostics. The obtained data indicated that the systems were capable of optoacoustic measurements and mapping of cerebral blood oxygenation in adults and in neonates, detection of intracranial hematomas, oxygenation measurements both from cerebral and central blood vessels and from cerebral tissues.

    Original languageEnglish (US)
    Title of host publicationSeventh European Workshop on Optical Fibre Sensors
    EditorsKyriacos Kalli, Gilberto Brambilla, Sinead O'Keeffe
    PublisherSPIE
    ISBN (Electronic)9781510631236
    DOIs
    StatePublished - Jan 1 2019
    Event7th European Workshop on Optical Fibre Sensors, EWOFS 2019 - Limassol, Cyprus
    Duration: Oct 1 2019Oct 4 2019

    Publication series

    NameProceedings of SPIE - The International Society for Optical Engineering
    Volume11199
    ISSN (Print)0277-786X
    ISSN (Electronic)1996-756X

    Conference

    Conference7th European Workshop on Optical Fibre Sensors, EWOFS 2019
    CountryCyprus
    CityLimassol
    Period10/1/1910/4/19

    Fingerprint

    Biomedical Imaging
    Photoacoustic effect
    Fiber Optics
    Fiber optics
    fiber optics
    Sensing
    Probe
    Blood Vessels
    Monitoring
    Imaging techniques
    probes
    Animals
    Tissue
    Imaging
    Diffusion Limit
    oxygenation
    Signal Detection
    Laser Diode
    Thermoelastic
    Phantom

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Condensed Matter Physics
    • Computer Science Applications
    • Applied Mathematics
    • Electrical and Electronic Engineering

    Cite this

    Esenaliev, R. (2019). Fiber-optic probes for biomedical optoacoustic imaging, monitoring, and sensing. In K. Kalli, G. Brambilla, & S. O'Keeffe (Eds.), Seventh European Workshop on Optical Fibre Sensors [111990W] (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 11199). SPIE. https://doi.org/10.1117/12.2539195

    Fiber-optic probes for biomedical optoacoustic imaging, monitoring, and sensing. / Esenaliev, Rinat.

    Seventh European Workshop on Optical Fibre Sensors. ed. / Kyriacos Kalli; Gilberto Brambilla; Sinead O'Keeffe. SPIE, 2019. 111990W (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 11199).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Esenaliev, R 2019, Fiber-optic probes for biomedical optoacoustic imaging, monitoring, and sensing. in K Kalli, G Brambilla & S O'Keeffe (eds), Seventh European Workshop on Optical Fibre Sensors., 111990W, Proceedings of SPIE - The International Society for Optical Engineering, vol. 11199, SPIE, 7th European Workshop on Optical Fibre Sensors, EWOFS 2019, Limassol, Cyprus, 10/1/19. https://doi.org/10.1117/12.2539195
    Esenaliev R. Fiber-optic probes for biomedical optoacoustic imaging, monitoring, and sensing. In Kalli K, Brambilla G, O'Keeffe S, editors, Seventh European Workshop on Optical Fibre Sensors. SPIE. 2019. 111990W. (Proceedings of SPIE - The International Society for Optical Engineering). https://doi.org/10.1117/12.2539195
    Esenaliev, Rinat. / Fiber-optic probes for biomedical optoacoustic imaging, monitoring, and sensing. Seventh European Workshop on Optical Fibre Sensors. editor / Kyriacos Kalli ; Gilberto Brambilla ; Sinead O'Keeffe. SPIE, 2019. (Proceedings of SPIE - The International Society for Optical Engineering).
    @inproceedings{f275ce13e41143b2b7b9b1e7c6e78dfa,
    title = "Fiber-optic probes for biomedical optoacoustic imaging, monitoring, and sensing",
    abstract = "We proposed biomedical optoacoustics/photoacoustics more than 25 years ago and developed this technology for imaging, monitoring, and sensing applications [1-35]. Optoacoustic diagnostic modality is based on thermoelastic generation of optoacoustic waves and combines high optical contrast and ultrasound spatial resolution. We developed optoacoustic systems (including highly-compact, multi-wavelength, fibercoupled, FDA-compliant laser diode systems) with fiber-optic, ultra-sensitive, wide-band optoacoustic probes. We tested them in small and large animal studies and in clinical studies in healthy volunteers and patients with traumatic brain injury and circulatory shock as well as in neonatal and fetal patients. The high sensitivity and bandwidth of the fiber-optic optoacoustic probes allowed for: 1) signal detection from tissues at depths well beyond the optical diffusion limit (up to several centimeters); 2) detection of microscopic tissue volumes; 3) optoacoustic imaging in large tissue phantoms and tissues with high resolution; 4) monitoring of tissue thermotherapy; 5) noninvasive probing of cerebral tissues in large animals and in humans (both neonates and adults); 6) accurate oxygenation measurements in humans in tissues and in specific blood vessels; and 7) optoacoustic waves therapeutic effects that can be used for noninvasive optoacoustic theranostics. The obtained data indicated that the systems were capable of optoacoustic measurements and mapping of cerebral blood oxygenation in adults and in neonates, detection of intracranial hematomas, oxygenation measurements both from cerebral and central blood vessels and from cerebral tissues.",
    author = "Rinat Esenaliev",
    year = "2019",
    month = "1",
    day = "1",
    doi = "10.1117/12.2539195",
    language = "English (US)",
    series = "Proceedings of SPIE - The International Society for Optical Engineering",
    publisher = "SPIE",
    editor = "Kyriacos Kalli and Gilberto Brambilla and Sinead O'Keeffe",
    booktitle = "Seventh European Workshop on Optical Fibre Sensors",

    }

    TY - GEN

    T1 - Fiber-optic probes for biomedical optoacoustic imaging, monitoring, and sensing

    AU - Esenaliev, Rinat

    PY - 2019/1/1

    Y1 - 2019/1/1

    N2 - We proposed biomedical optoacoustics/photoacoustics more than 25 years ago and developed this technology for imaging, monitoring, and sensing applications [1-35]. Optoacoustic diagnostic modality is based on thermoelastic generation of optoacoustic waves and combines high optical contrast and ultrasound spatial resolution. We developed optoacoustic systems (including highly-compact, multi-wavelength, fibercoupled, FDA-compliant laser diode systems) with fiber-optic, ultra-sensitive, wide-band optoacoustic probes. We tested them in small and large animal studies and in clinical studies in healthy volunteers and patients with traumatic brain injury and circulatory shock as well as in neonatal and fetal patients. The high sensitivity and bandwidth of the fiber-optic optoacoustic probes allowed for: 1) signal detection from tissues at depths well beyond the optical diffusion limit (up to several centimeters); 2) detection of microscopic tissue volumes; 3) optoacoustic imaging in large tissue phantoms and tissues with high resolution; 4) monitoring of tissue thermotherapy; 5) noninvasive probing of cerebral tissues in large animals and in humans (both neonates and adults); 6) accurate oxygenation measurements in humans in tissues and in specific blood vessels; and 7) optoacoustic waves therapeutic effects that can be used for noninvasive optoacoustic theranostics. The obtained data indicated that the systems were capable of optoacoustic measurements and mapping of cerebral blood oxygenation in adults and in neonates, detection of intracranial hematomas, oxygenation measurements both from cerebral and central blood vessels and from cerebral tissues.

    AB - We proposed biomedical optoacoustics/photoacoustics more than 25 years ago and developed this technology for imaging, monitoring, and sensing applications [1-35]. Optoacoustic diagnostic modality is based on thermoelastic generation of optoacoustic waves and combines high optical contrast and ultrasound spatial resolution. We developed optoacoustic systems (including highly-compact, multi-wavelength, fibercoupled, FDA-compliant laser diode systems) with fiber-optic, ultra-sensitive, wide-band optoacoustic probes. We tested them in small and large animal studies and in clinical studies in healthy volunteers and patients with traumatic brain injury and circulatory shock as well as in neonatal and fetal patients. The high sensitivity and bandwidth of the fiber-optic optoacoustic probes allowed for: 1) signal detection from tissues at depths well beyond the optical diffusion limit (up to several centimeters); 2) detection of microscopic tissue volumes; 3) optoacoustic imaging in large tissue phantoms and tissues with high resolution; 4) monitoring of tissue thermotherapy; 5) noninvasive probing of cerebral tissues in large animals and in humans (both neonates and adults); 6) accurate oxygenation measurements in humans in tissues and in specific blood vessels; and 7) optoacoustic waves therapeutic effects that can be used for noninvasive optoacoustic theranostics. The obtained data indicated that the systems were capable of optoacoustic measurements and mapping of cerebral blood oxygenation in adults and in neonates, detection of intracranial hematomas, oxygenation measurements both from cerebral and central blood vessels and from cerebral tissues.

    UR - http://www.scopus.com/inward/record.url?scp=85073384666&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=85073384666&partnerID=8YFLogxK

    U2 - 10.1117/12.2539195

    DO - 10.1117/12.2539195

    M3 - Conference contribution

    AN - SCOPUS:85073384666

    T3 - Proceedings of SPIE - The International Society for Optical Engineering

    BT - Seventh European Workshop on Optical Fibre Sensors

    A2 - Kalli, Kyriacos

    A2 - Brambilla, Gilberto

    A2 - O'Keeffe, Sinead

    PB - SPIE

    ER -