Abstract
Filipin-cholesterol complexes which are visible in freeze-fracture preparations were used as a probe to explore special domains in the sarcoplasmic reticulum (SR), the plasmalemma, and other membranes of mouse and finch cardiac muscle. The question was especially raised as to whether or not a predilection of filipin-cholesterol complexes for the junctional sarcoplasmic reticulum could be established in cardiac muscle as it was found to exist in skeletal muscle. No such predilection was discovered. Filipin-cholesterol complexes were observed mainly in the plasmalemma, in the sarcoplasmic reticulum, and in mitochondria of cardiac muscle cells. In the SR they were very rare. In the sarcolemma they occurred in patches while, sometimes, they densely populated the entire cell surface.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 98-103 |
| Number of pages | 6 |
| Journal | Journal of Ultrasructure Research |
| Volume | 80 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1982 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Molecular Biology
- Anatomy
Cite this
Filipin-sterol complexes in the membranes of cardiac muscle. / Sommer, Joachim R.; Dolber, Paul C.; Taylor, I.
In: Journal of Ultrasructure Research, Vol. 80, No. 1, 1982, p. 98-103.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Filipin-sterol complexes in the membranes of cardiac muscle
AU - Sommer, Joachim R.
AU - Dolber, Paul C.
AU - Taylor, I.
PY - 1982
Y1 - 1982
N2 - Filipin-cholesterol complexes which are visible in freeze-fracture preparations were used as a probe to explore special domains in the sarcoplasmic reticulum (SR), the plasmalemma, and other membranes of mouse and finch cardiac muscle. The question was especially raised as to whether or not a predilection of filipin-cholesterol complexes for the junctional sarcoplasmic reticulum could be established in cardiac muscle as it was found to exist in skeletal muscle. No such predilection was discovered. Filipin-cholesterol complexes were observed mainly in the plasmalemma, in the sarcoplasmic reticulum, and in mitochondria of cardiac muscle cells. In the SR they were very rare. In the sarcolemma they occurred in patches while, sometimes, they densely populated the entire cell surface.
AB - Filipin-cholesterol complexes which are visible in freeze-fracture preparations were used as a probe to explore special domains in the sarcoplasmic reticulum (SR), the plasmalemma, and other membranes of mouse and finch cardiac muscle. The question was especially raised as to whether or not a predilection of filipin-cholesterol complexes for the junctional sarcoplasmic reticulum could be established in cardiac muscle as it was found to exist in skeletal muscle. No such predilection was discovered. Filipin-cholesterol complexes were observed mainly in the plasmalemma, in the sarcoplasmic reticulum, and in mitochondria of cardiac muscle cells. In the SR they were very rare. In the sarcolemma they occurred in patches while, sometimes, they densely populated the entire cell surface.
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UR - http://www.scopus.com/inward/citedby.url?scp=0019977083&partnerID=8YFLogxK
U2 - 10.1016/S0022-5320(82)80035-X
DO - 10.1016/S0022-5320(82)80035-X
M3 - Article
VL - 80
SP - 98
EP - 103
JO - Journal of Structural Biology
JF - Journal of Structural Biology
SN - 1047-8477
IS - 1
ER -