Findings on PET/CT-PET/MR secondary to central and peripheral nervous system infection by SARS-CoV-2

Introduction: SARS-CoV-2 infection worldwide has affected about 232,075,351 people and caused at least 4,752,988 deaths according to WHO data. It has been considered that the organ of predilection for involvement by this infection is the lung, but according to the literature, 36.4% of patients have evidenced CNS involvement and 8.9% of the SNP. Materials and methods: An intentional search of the literature was carried out in different medical databases such as Pubmed, Ovid, BMJ, Clinical Key, ScienceDirect, entering keywords such as COVID-19, brain, SARS-CoV-2 infection, PET/CT, PET/RM encephalopathy, accompanied by Boolean operators such as AND, OR and NOT. Results: To date, numerous case reports, case series, and observational studies have been published using different PET/CT or PET/MRI radiotracers with different findings. Conclusion: PET/CT or PET/MRI with 2-[¹⁸F]FDG or [¹⁸F]FDOPA has shown to be a useful tool to detect and understand the disease process in those patients with SARS-CoV-2 neuro-infection in cases of normal structural images.