Fine-tuning the amphiphilicity: A crucial parameter in the design of potent α-phenyl-N-tert-butylnitrone analogues

Grégory Durand, Burkhard Poeggeler, Jutta Böker, Simon Raynal, Ange Polidori, Miguel A. Pappolla, Rüdiger Hardeland, Bernard Pucci

Research output: Contribution to journalArticle

21 Scopus citations


A new series of hydrophilic, lipophilic, and amphiphilic α-phenyl-N-tert-butylnitrone (PBN) derivatives were synthesized to explore the relationship between their hydrophilic-lipophilic properties and antioxidant potency. Very potent protective effects of amphiphilic lactobionamide and tris(hydroxymethyl)aminomethane PBN derivatives were observed in mitochondrial preparations, in cell cultures, and in rotifers exposed to unspecific and mitochondria targeted oxidotoxins.

Original languageEnglish (US)
Pages (from-to)3976-3979
Number of pages4
JournalJournal of Medicinal Chemistry
Issue number17
StatePublished - Aug 23 2007
Externally publishedYes


ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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