First- and second-trimester down syndrome screening markers in pregnancies achieved through assisted reproductive technologies (ART)

A FASTER trial study

G. Lambert-Messerlian, L. Dugoff, J. Vidaver, J. A. Canick, F. D. Malone, R. H. Ball, C. H. Comstock, D. A. Nyberg, George Saade, K. Eddleman, S. Klugman, S. D. Craigo, I. E. Timor-Tritsch, S. R. Carr, H. M. Wolfe, M. E. D'Alton

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Objective: To determine whether first- and second-trimester Down syndrome screening markers and screen-positive rates are altered in pregnancies conceived using assisted reproductive technologies (ARTs). Methods: ART pregnancies in the multicenter FASTER trial were identified. Marker levels were evaluated for five types of ART: in vitro fertilization with ovulation induction (IVF-OI), IVF with OI and egg donation (IVF-OI-ED), IVF with ED (IVF-ED), and intrauterine insemination with OI (IUI-OI) or without OI (IUI). Each group was compared to non-ART controls using Mann-Whitney U analysis. Results: First-trimester marker levels were not significantly different between ART and control pregnancies, with the exception of reduced PAPP-A levels in the IUI-OI group. In contrast, second-trimester inhibin A levels were increased in all ART pregnancies, estriol was reduced and human chorionic gonadotropin (hCG) was increased in IVF and IUI pregnancies without ED, and alpha-fetoprotein (AFP) was increased in ED pregnancies. Second-trimester screen-positive rates were significantly higher than expected for ART pregnancies, except when ED was used. Conclusions: These data show that ART significantly impacts second-, but not first-, trimester markers and screen-positive rates. The type of adjustment needed in second-trimester screening depends on the particular type of ART used.

Original languageEnglish
Pages (from-to)672-678
Number of pages7
JournalPrenatal Diagnosis
Volume26
Issue number8
DOIs
StatePublished - Aug 2006

Fingerprint

Assisted Reproductive Techniques
Second Pregnancy Trimester
First Pregnancy Trimester
Down Syndrome
Pregnancy
Insemination
Pregnancy-Associated Plasma Protein-A
Reproductive Techniques
Estriol
Ovulation Induction
alpha-Fetoproteins
Chorionic Gonadotropin
Fertilization in Vitro
Multicenter Studies
Ovum

Keywords

  • Assisted reproduction
  • Down syndrome
  • Maternal serum screening
  • Pregnancy

ASJC Scopus subject areas

  • Genetics(clinical)
  • Obstetrics and Gynecology

Cite this

Lambert-Messerlian, G., Dugoff, L., Vidaver, J., Canick, J. A., Malone, F. D., Ball, R. H., ... D'Alton, M. E. (2006). First- and second-trimester down syndrome screening markers in pregnancies achieved through assisted reproductive technologies (ART): A FASTER trial study. Prenatal Diagnosis, 26(8), 672-678. https://doi.org/10.1002/pd.1469

First- and second-trimester down syndrome screening markers in pregnancies achieved through assisted reproductive technologies (ART) : A FASTER trial study. / Lambert-Messerlian, G.; Dugoff, L.; Vidaver, J.; Canick, J. A.; Malone, F. D.; Ball, R. H.; Comstock, C. H.; Nyberg, D. A.; Saade, George; Eddleman, K.; Klugman, S.; Craigo, S. D.; Timor-Tritsch, I. E.; Carr, S. R.; Wolfe, H. M.; D'Alton, M. E.

In: Prenatal Diagnosis, Vol. 26, No. 8, 08.2006, p. 672-678.

Research output: Contribution to journalArticle

Lambert-Messerlian, G, Dugoff, L, Vidaver, J, Canick, JA, Malone, FD, Ball, RH, Comstock, CH, Nyberg, DA, Saade, G, Eddleman, K, Klugman, S, Craigo, SD, Timor-Tritsch, IE, Carr, SR, Wolfe, HM & D'Alton, ME 2006, 'First- and second-trimester down syndrome screening markers in pregnancies achieved through assisted reproductive technologies (ART): A FASTER trial study', Prenatal Diagnosis, vol. 26, no. 8, pp. 672-678. https://doi.org/10.1002/pd.1469
Lambert-Messerlian, G. ; Dugoff, L. ; Vidaver, J. ; Canick, J. A. ; Malone, F. D. ; Ball, R. H. ; Comstock, C. H. ; Nyberg, D. A. ; Saade, George ; Eddleman, K. ; Klugman, S. ; Craigo, S. D. ; Timor-Tritsch, I. E. ; Carr, S. R. ; Wolfe, H. M. ; D'Alton, M. E. / First- and second-trimester down syndrome screening markers in pregnancies achieved through assisted reproductive technologies (ART) : A FASTER trial study. In: Prenatal Diagnosis. 2006 ; Vol. 26, No. 8. pp. 672-678.
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T2 - A FASTER trial study

AU - Lambert-Messerlian, G.

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AU - Vidaver, J.

AU - Canick, J. A.

AU - Malone, F. D.

AU - Ball, R. H.

AU - Comstock, C. H.

AU - Nyberg, D. A.

AU - Saade, George

AU - Eddleman, K.

AU - Klugman, S.

AU - Craigo, S. D.

AU - Timor-Tritsch, I. E.

AU - Carr, S. R.

AU - Wolfe, H. M.

AU - D'Alton, M. E.

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N2 - Objective: To determine whether first- and second-trimester Down syndrome screening markers and screen-positive rates are altered in pregnancies conceived using assisted reproductive technologies (ARTs). Methods: ART pregnancies in the multicenter FASTER trial were identified. Marker levels were evaluated for five types of ART: in vitro fertilization with ovulation induction (IVF-OI), IVF with OI and egg donation (IVF-OI-ED), IVF with ED (IVF-ED), and intrauterine insemination with OI (IUI-OI) or without OI (IUI). Each group was compared to non-ART controls using Mann-Whitney U analysis. Results: First-trimester marker levels were not significantly different between ART and control pregnancies, with the exception of reduced PAPP-A levels in the IUI-OI group. In contrast, second-trimester inhibin A levels were increased in all ART pregnancies, estriol was reduced and human chorionic gonadotropin (hCG) was increased in IVF and IUI pregnancies without ED, and alpha-fetoprotein (AFP) was increased in ED pregnancies. Second-trimester screen-positive rates were significantly higher than expected for ART pregnancies, except when ED was used. Conclusions: These data show that ART significantly impacts second-, but not first-, trimester markers and screen-positive rates. The type of adjustment needed in second-trimester screening depends on the particular type of ART used.

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KW - Down syndrome

KW - Maternal serum screening

KW - Pregnancy

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