TY - JOUR
T1 - Fitness of pandemic H1N1 and seasonal influenza a viruses during co-infection
AU - Perez, Daniel Roberto
AU - Sorrell, Erin
AU - Angel, Matthew
AU - Ye, Jianqiang
AU - Hickman, Danielle
AU - Pena, Lindomar
AU - Ramirez-Nieto, Gloria
AU - Kimble, Brian
AU - Araya, Yonas
PY - 2009
Y1 - 2009
N2 - On June 11, 2009 the World Health Organization (WHO) declared a new H1N1 influenza pandemic. This pandemic strain is as transmissible as seasonal H1N1 and H3N2 influenza A viruses. Major concerns facing this pandemic are whether the new virus will replace, co-circulate and/or reassort with seasonal H1N1 and/or H3N2 human strains. Using the ferret model, we investigated which of these three possibilities were most likely favored. Our studies showed that the current pandemic virus is more transmissible than, and has a biological advantage over, prototypical seasonal H1 or H3 strains.
AB - On June 11, 2009 the World Health Organization (WHO) declared a new H1N1 influenza pandemic. This pandemic strain is as transmissible as seasonal H1N1 and H3N2 influenza A viruses. Major concerns facing this pandemic are whether the new virus will replace, co-circulate and/or reassort with seasonal H1N1 and/or H3N2 human strains. Using the ferret model, we investigated which of these three possibilities were most likely favored. Our studies showed that the current pandemic virus is more transmissible than, and has a biological advantage over, prototypical seasonal H1 or H3 strains.
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U2 - 10.1371/currents.RRN1011
DO - 10.1371/currents.RRN1011
M3 - Article
C2 - 20029606
AN - SCOPUS:84873461890
SN - 2157-3999
SP - 1
EP - 10
JO - PLoS Currents
JF - PLoS Currents
IS - AUG
ER -