Fitness of pandemic H1N1 and seasonal influenza a viruses during co-infection

Daniel Roberto Perez, Erin Sorrell, Matthew Angel, Jianqiang Ye, Danielle Hickman, Lindomar Pena, Gloria Ramirez-Nieto, Brian Kimble, Yonas Araya

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

On June 11, 2009 the World Health Organization (WHO) declared a new H1N1 influenza pandemic. This pandemic strain is as transmissible as seasonal H1N1 and H3N2 influenza A viruses. Major concerns facing this pandemic are whether the new virus will replace, co-circulate and/or reassort with seasonal H1N1 and/or H3N2 human strains. Using the ferret model, we investigated which of these three possibilities were most likely favored. Our studies showed that the current pandemic virus is more transmissible than, and has a biological advantage over, prototypical seasonal H1 or H3 strains.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalPLoS Currents
Issue numberAUG
DOIs
StatePublished - 2009
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Perez, D. R., Sorrell, E., Angel, M., Ye, J., Hickman, D., Pena, L., Ramirez-Nieto, G., Kimble, B., & Araya, Y. (2009). Fitness of pandemic H1N1 and seasonal influenza a viruses during co-infection. PLoS Currents, (AUG), 1-10. https://doi.org/10.1371/currents.RRN1011