FIVE-YEAR OUTCOMES AFTER LONG-TERM OXANDROLONE ADMINISTRATION IN SEVERELY BURNED CHILDREN: A RANDOMIZED CLINICAL TRIAL

Patrick T. Reeves, David Herndon, Jessica D. Tanksley, Kristofer Jennings, Gordon L. Klein, Ronald P. Mlcak, Robert P. Clayton, Nancy N. Crites, Joshua P. Hays, Clark Andersen, Jong Lee, Walter Meyer, Oscar Suman, Celeste Finnerty

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

ABSTRACT: Administration of oxandrolone, a non-aromatizable testosterone analog, to children for 12 months following severe burn injury has been shown to improve height, increase bone mineral content (BMC), reduce cardiac work, and augment muscle strength. Surprisingly, the increase in BMC persists well beyond the period of oxandrolone administration. This study was undertaken to determine if administration of oxandrolone for 2 years yields greater effects on long-term BMC and bone mineral density (BMD). Patients between 0 and 18 years of age with ≥30% of total body surface area burned were consented to an IRB-approved protocol and randomized to receive either placebo (n?=?84) or 0.1?mg/kg oxandrolone orally twice daily for 24 months (n?=?35). Patients were followed prospectively from the time of admission until 5 years post burn in a single-center, intent-to-treat setting. Height, weight, BMC, and BMD were recorded annually through 5 years post injury. The long-term administration of oxandrolone for 16?±?1 months postburn (range, 12.1 to 25.2 months) significantly increased whole-body (WB) BMC (p?

Original languageEnglish (US)
JournalShock
DOIs
StateAccepted/In press - Oct 19 2015

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Oxandrolone
Bone Density
Randomized Controlled Trials
Research Ethics Committees
Body Surface Area
Wounds and Injuries
Muscle Strength
Testosterone
Placebos
Weights and Measures

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Emergency Medicine

Cite this

FIVE-YEAR OUTCOMES AFTER LONG-TERM OXANDROLONE ADMINISTRATION IN SEVERELY BURNED CHILDREN : A RANDOMIZED CLINICAL TRIAL. / Reeves, Patrick T.; Herndon, David; Tanksley, Jessica D.; Jennings, Kristofer; Klein, Gordon L.; Mlcak, Ronald P.; Clayton, Robert P.; Crites, Nancy N.; Hays, Joshua P.; Andersen, Clark; Lee, Jong; Meyer, Walter; Suman, Oscar; Finnerty, Celeste.

In: Shock, 19.10.2015.

Research output: Contribution to journalArticle

Reeves, Patrick T. ; Herndon, David ; Tanksley, Jessica D. ; Jennings, Kristofer ; Klein, Gordon L. ; Mlcak, Ronald P. ; Clayton, Robert P. ; Crites, Nancy N. ; Hays, Joshua P. ; Andersen, Clark ; Lee, Jong ; Meyer, Walter ; Suman, Oscar ; Finnerty, Celeste. / FIVE-YEAR OUTCOMES AFTER LONG-TERM OXANDROLONE ADMINISTRATION IN SEVERELY BURNED CHILDREN : A RANDOMIZED CLINICAL TRIAL. In: Shock. 2015.
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