ABSTRACT: Administration of oxandrolone, a non-aromatizable testosterone analog, to children for 12 months following severe burn injury has been shown to improve height, increase bone mineral content (BMC), reduce cardiac work, and augment muscle strength. Surprisingly, the increase in BMC persists well beyond the period of oxandrolone administration. This study was undertaken to determine if administration of oxandrolone for 2 years yields greater effects on long-term BMC and bone mineral density (BMD). Patients between 0 and 18 years of age with ≥30% of total body surface area burned were consented to an IRB-approved protocol and randomized to receive either placebo (n?=?84) or 0.1?mg/kg oxandrolone orally twice daily for 24 months (n?=?35). Patients were followed prospectively from the time of admission until 5 years post burn in a single-center, intent-to-treat setting. Height, weight, BMC, and BMD were recorded annually through 5 years post injury. The long-term administration of oxandrolone for 16?±?1 months postburn (range, 12.1 to 25.2 months) significantly increased whole-body (WB) BMC (p?
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine
- Emergency Medicine