Flaviviral RNA structures and their role in replication and immunity

Katell Bidet, Mariano Garcia-Blanco

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

More than simple vectors of genetic information, flaviviral RNAs have emerged as critical regulators of the virus life cycle. Viral RNAs regulate interactions with viral and cellular proteins in both, mosquito and mammalian hosts to ultimately influence processes as diverse as RNA replication, translation, packaging or pathogenicity. In this chapter, we will review the current knowledge of the role of sequence and structures in the flaviviral RNA in viral propagation and interaction with the host cell. We will also cover the increasing body of evidence linking viral non-coding RNAs with pathogenicity, host immunity and epidemic potential.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages45-62
Number of pages18
DOIs
StatePublished - Jan 1 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1062
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Flavivirus
  • Pathogenesis
  • Replication
  • RNA
  • Structures

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Bidet, K., & Garcia-Blanco, M. (2018). Flaviviral RNA structures and their role in replication and immunity. In Advances in Experimental Medicine and Biology (pp. 45-62). (Advances in Experimental Medicine and Biology; Vol. 1062). Springer New York LLC. https://doi.org/10.1007/978-981-10-8727-1_4