Flaviviral RNAs: Weapons and targets in the war between virus and host

Katell Bidet, Mariano Garcia-Blanco

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Flaviviruses are a genus of (+)ssRNA (positive ssRNA) enveloped viruses that replicate in the cytoplasm of cells of diverse species from arthropods to mammals. Many are important human pathogens such as DENV-1-4 (dengue virus types 1-4), WNV (West Nile virus), YFV (yellow fever virus), JEV (Japanese encephalitis virus) and TBEV (tick-borne encephalitis). Given their RNA genomes it is not surprising that flaviviral life cycles revolve around critical RNA transactions. It is these we highlight in the present article. First, we summarize the mechanisms governing flaviviral replication and the central role of conserved RNA elements and viral protein-RNA interactions in RNA synthesis, translation and packaging. Secondly, we focus on how host RNA-binding proteins both benefit and inhibit flaviviral replication at different stages of their life cycle in mammalian hosts. Thirdly, we cover recent studies on viral non-coding RNAs produced in flavivirus-infected cells and how these RNAs affect various aspects of cellular RNA metabolism. Together, the article puts into perspective the central role of flaviviral RNAs in modulating both viral and cellular functions.

Original languageEnglish (US)
Pages (from-to)215-230
Number of pages16
JournalBiochemical Journal
Volume462
Issue number2
DOIs
StatePublished - Sep 1 2014
Externally publishedYes

Fingerprint

Weapons
Viruses
RNA
Flavivirus
Viral RNA
Life Cycle Stages
Japanese Encephalitis Virus
Life cycle
Yellow fever virus
Tick-Borne Encephalitis
West Nile virus
Untranslated RNA
Dengue Virus
RNA-Binding Proteins
Arthropods
Viral Proteins
Product Packaging
Mammals
Warfare
Pathogens

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Flaviviral RNAs : Weapons and targets in the war between virus and host. / Bidet, Katell; Garcia-Blanco, Mariano.

In: Biochemical Journal, Vol. 462, No. 2, 01.09.2014, p. 215-230.

Research output: Contribution to journalArticle

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