Flaviviridae

E. G. Westaway; M. A. Brinton; S. Y.A. Gaidamovich; M. C. Horzinek; A. Igarashi; L. Kääriäinen; D. K. Lvov; J. S. Porterfield; P. K. Russell; D. W. Trent

doi:10.1159/000149642

Flaviviridae

E. G. Westaway, M. A. Brinton, S. Y.A. Gaidamovich, M. C. Horzinek, A. Igarashi, L. Kääriäinen, D. K. Lvov, J. S. Porterfield, P. K. Russell, D. W. Trent

Research output: Contribution to journal › Article › peer-review

331 Scopus citations

Abstract

The family Flaviviridae comprises the genus Flavivirus. which contains 65 related species and two possible members. They are small, enveloped RNA viruses (diameter 45 nm) with peplomers comprising a single glycoprotein E. Other structural proteins are designated C (core) and M (membrane-like). The single strand of RNA is infectious and has a molecular weight of about 4 × 10⁶ and an m⁷G ‘cap’ at the 5′ end but no poly(A) tract at the 3′ end: It functions as the sole messenger. The gene sequence commences 5′-C-M-E… The replication strategy and the mode of morphogenesis are distinct from those of the Togaviridae which are slightly larger and morphologically similar in some respects. Flaviviruses infect a wide range of vertebrates, and many are transmitted by arthropods.

Original language	English (US)
Pages (from-to)	183-192
Number of pages	10
Journal	Intervirology
Volume	24
Issue number	4
DOIs	https://doi.org/10.1159/000149642
State	Published - 1985
Externally published	Yes

Keywords

Flavivirus
Viral taxonomy

ASJC Scopus subject areas

Virology
Infectious Diseases

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10.1159/000149642

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title = "Flaviviridae",

abstract = "The family Flaviviridae comprises the genus Flavivirus. which contains 65 related species and two possible members. They are small, enveloped RNA viruses (diameter 45 nm) with peplomers comprising a single glycoprotein E. Other structural proteins are designated C (core) and M (membrane-like). The single strand of RNA is infectious and has a molecular weight of about 4 × 106 and an m7G {\textquoteleft}cap{\textquoteright} at the 5′ end but no poly(A) tract at the 3′ end: It functions as the sole messenger. The gene sequence commences 5′-C-M-E… The replication strategy and the mode of morphogenesis are distinct from those of the Togaviridae which are slightly larger and morphologically similar in some respects. Flaviviruses infect a wide range of vertebrates, and many are transmitted by arthropods.",

keywords = "Flavivirus, Viral taxonomy",

author = "Westaway, {E. G.} and Brinton, {M. A.} and Gaidamovich, {S. Y.A.} and Horzinek, {M. C.} and A. Igarashi and L. K{\"a}{\"a}ri{\"a}inen and Lvov, {D. K.} and Porterfield, {J. S.} and Russell, {P. K.} and Trent, {D. W.}",

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doi = "10.1159/000149642",

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AU - Westaway, E. G.

AU - Brinton, M. A.

AU - Gaidamovich, S. Y.A.

AU - Horzinek, M. C.

AU - Igarashi, A.

AU - Kääriäinen, L.

AU - Lvov, D. K.

AU - Porterfield, J. S.

AU - Russell, P. K.

AU - Trent, D. W.

PY - 1985

Y1 - 1985

N2 - The family Flaviviridae comprises the genus Flavivirus. which contains 65 related species and two possible members. They are small, enveloped RNA viruses (diameter 45 nm) with peplomers comprising a single glycoprotein E. Other structural proteins are designated C (core) and M (membrane-like). The single strand of RNA is infectious and has a molecular weight of about 4 × 106 and an m7G ‘cap’ at the 5′ end but no poly(A) tract at the 3′ end: It functions as the sole messenger. The gene sequence commences 5′-C-M-E… The replication strategy and the mode of morphogenesis are distinct from those of the Togaviridae which are slightly larger and morphologically similar in some respects. Flaviviruses infect a wide range of vertebrates, and many are transmitted by arthropods.

AB - The family Flaviviridae comprises the genus Flavivirus. which contains 65 related species and two possible members. They are small, enveloped RNA viruses (diameter 45 nm) with peplomers comprising a single glycoprotein E. Other structural proteins are designated C (core) and M (membrane-like). The single strand of RNA is infectious and has a molecular weight of about 4 × 106 and an m7G ‘cap’ at the 5′ end but no poly(A) tract at the 3′ end: It functions as the sole messenger. The gene sequence commences 5′-C-M-E… The replication strategy and the mode of morphogenesis are distinct from those of the Togaviridae which are slightly larger and morphologically similar in some respects. Flaviviruses infect a wide range of vertebrates, and many are transmitted by arthropods.

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KW - Viral taxonomy

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JO - Intervirology

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Flaviviridae

Abstract

Keywords

ASJC Scopus subject areas

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