Flaviviridae

E. G. Westaway, M. A. Brinton, S. Y.A. Gaidamovich, M. C. Horzinek, A. Igarashi, L. Kääriäinen, D. K. Lvov, J. S. Porterfield, P. K. Russell, D. W. Trent

Research output: Contribution to journalArticle

303 Scopus citations

Abstract

The family Flaviviridae comprises the genus Flavivirus. which contains 65 related species and two possible members. They are small, enveloped RNA viruses (diameter 45 nm) with peplomers comprising a single glycoprotein E. Other structural proteins are designated C (core) and M (membrane-like). The single strand of RNA is infectious and has a molecular weight of about 4 × 106 and an m7G ‘cap’ at the 5′ end but no poly(A) tract at the 3′ end: It functions as the sole messenger. The gene sequence commences 5′-C-M-E… The replication strategy and the mode of morphogenesis are distinct from those of the Togaviridae which are slightly larger and morphologically similar in some respects. Flaviviruses infect a wide range of vertebrates, and many are transmitted by arthropods.

Original languageEnglish (US)
Pages (from-to)183-192
Number of pages10
JournalIntervirology
Volume24
Issue number4
DOIs
StatePublished - Jan 1 1985

Keywords

  • Flavivirus
  • Viral taxonomy

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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  • Cite this

    Westaway, E. G., Brinton, M. A., Gaidamovich, S. Y. A., Horzinek, M. C., Igarashi, A., Kääriäinen, L., Lvov, D. K., Porterfield, J. S., Russell, P. K., & Trent, D. W. (1985). Flaviviridae. Intervirology, 24(4), 183-192. https://doi.org/10.1159/000149642