Flaviviridae

E. G. Westaway, M. A. Brinton, S. Y. Gaidamovich, M. C. Horzinek, A. Igarashi, L. Kääriäinen, D. K. Lvov, J. S. Porterfield, P. K. Russell, D. W. Trent

Research output: Contribution to journalArticle

293 Citations (Scopus)

Abstract

The family Flaviviridae comprises the genus Flavivirus, which contains 65 related species and two possible members. They are small, enveloped RNA viruses (diameter 45 nm) with peplomers comprising a single glycoprotein E. Other structural proteins are designated C (core) and M (membrane-like). The single strand of RNA is infectious and has a molecular weight of about 4 x 106 and an m7G 'cap' at the 5' end but no poly(A) tract at the 3' end; it functions as the sole messenger. The gene sequence commences 5'-C-M-E... The replication strategy and the mode of morphogenesis are distinct from those of the Togaviridae which are slightly larger and morphologically similar in some respects. Flaviviruses infect a wide range of vertebrates, and many are transmitted by arthropods.

Original languageEnglish (US)
Pages (from-to)183-192
Number of pages10
JournalIntervirology
Volume24
Issue number4
StatePublished - 1985

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Flaviviridae
Flavivirus
Togaviridae
Poly A
Arthropods
RNA Viruses
Protein C
Morphogenesis
Vertebrates
Glycoproteins
Molecular Weight
RNA
Membranes
Genes

ASJC Scopus subject areas

  • Virology

Cite this

Westaway, E. G., Brinton, M. A., Gaidamovich, S. Y., Horzinek, M. C., Igarashi, A., Kääriäinen, L., ... Trent, D. W. (1985). Flaviviridae. Intervirology, 24(4), 183-192.

Flaviviridae. / Westaway, E. G.; Brinton, M. A.; Gaidamovich, S. Y.; Horzinek, M. C.; Igarashi, A.; Kääriäinen, L.; Lvov, D. K.; Porterfield, J. S.; Russell, P. K.; Trent, D. W.

In: Intervirology, Vol. 24, No. 4, 1985, p. 183-192.

Research output: Contribution to journalArticle

Westaway, EG, Brinton, MA, Gaidamovich, SY, Horzinek, MC, Igarashi, A, Kääriäinen, L, Lvov, DK, Porterfield, JS, Russell, PK & Trent, DW 1985, 'Flaviviridae', Intervirology, vol. 24, no. 4, pp. 183-192.
Westaway EG, Brinton MA, Gaidamovich SY, Horzinek MC, Igarashi A, Kääriäinen L et al. Flaviviridae. Intervirology. 1985;24(4):183-192.
Westaway, E. G. ; Brinton, M. A. ; Gaidamovich, S. Y. ; Horzinek, M. C. ; Igarashi, A. ; Kääriäinen, L. ; Lvov, D. K. ; Porterfield, J. S. ; Russell, P. K. ; Trent, D. W. / Flaviviridae. In: Intervirology. 1985 ; Vol. 24, No. 4. pp. 183-192.
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