Flaviviruses, an expanding threat in public health

focus on dengue, West Nile, and Japanese encephalitis virus

Carlo Amorin Daep, Jorge L. Muñoz-Jordán, Eliseo Eugenin

Research output: Contribution to journalReview article

53 Citations (Scopus)

Abstract

The flaviviruses dengue, West Nile, and Japanese encephalitis represent three major mosquito-borne viruses worldwide. These pathogens impact the lives of millions of individuals and potentially could affect non-endemic areas already colonized by mosquito vectors. Unintentional transport of infected vectors (Aedes and Culex spp.), traveling within endemic areas, rapid adaptation of the insects into new geographic locations, climate change, and lack of medical surveillance have greatly contributed to the increase in flaviviral infections worldwide. The mechanisms by which flaviviruses alter the immune and the central nervous system have only recently been examined despite the alarming number of infections, related deaths, and increasing global distribution. In this review, we will discuss the expansion of the geographic areas affected by flaviviruses, the potential threats to previously unaffected countries, the mechanisms of pathogenesis, and the potential therapeutic interventions to limit the devastating consequences of these viruses.

Original languageEnglish (US)
Pages (from-to)539-560
Number of pages22
JournalJournal of NeuroVirology
Volume20
Issue number6
DOIs
StatePublished - Dec 12 2014
Externally publishedYes

Fingerprint

Japanese Encephalitis Virus
Flavivirus
Dengue
Public Health
Japanese Encephalitis
Viruses
Geographic Locations
Culex
Aedes
Climate Change
Infection
Culicidae
Insects
Central Nervous System

Keywords

  • Bioterrorism
  • Brain
  • Fever
  • Mosquito
  • Vaccines

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

Cite this

Flaviviruses, an expanding threat in public health : focus on dengue, West Nile, and Japanese encephalitis virus. / Daep, Carlo Amorin; Muñoz-Jordán, Jorge L.; Eugenin, Eliseo.

In: Journal of NeuroVirology, Vol. 20, No. 6, 12.12.2014, p. 539-560.

Research output: Contribution to journalReview article

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