Flaviviruses—Induced Neurological Sequelae

Samantha Gabrielle Cody; Awadalkareem Adam; Andrei Siniavin; Sam S. Kang; Tian Wang

doi:10.3390/pathogens14010022

Flaviviruses—Induced Neurological Sequelae

Samantha Gabrielle Cody, Awadalkareem Adam, Andrei Siniavin, Sam S. Kang, Tian Wang

Microbiology And Immunology

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Flaviviruses, a group of single-stranded RNA viruses spread by mosquitoes or ticks, include several significant neurotropic viruses, such as West Nile virus (WNV), Japanese encephalitis virus (JEV), tick-borne encephalitis virus (TBEV), and Zika virus (ZIKV). These viruses can cause a range of neurological diseases during acute infection, from mild, flu-like symptoms to severe and fatal encephalitis. A total of 20–50% of patients who recovered from acute flavivirus infections experienced long-term cognitive issues. Here, we discuss these major neurotropic flaviviruses-induced clinical diseases in humans and the recent findings in animal models and provide insights into the underlying disease mechanisms.

Original language	English (US)
Article number	22
Journal	Pathogens
Volume	14
Issue number	1
DOIs	https://doi.org/10.3390/pathogens14010022
State	Published - Jan 2025

Keywords

animal models
flavivirus
neurological sequelae
neurotropic

ASJC Scopus subject areas

Immunology and Allergy
Molecular Biology
General Immunology and Microbiology
Microbiology (medical)
Infectious Diseases

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10.3390/pathogens14010022

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title = "Flaviviruses—Induced Neurological Sequelae",

abstract = "Flaviviruses, a group of single-stranded RNA viruses spread by mosquitoes or ticks, include several significant neurotropic viruses, such as West Nile virus (WNV), Japanese encephalitis virus (JEV), tick-borne encephalitis virus (TBEV), and Zika virus (ZIKV). These viruses can cause a range of neurological diseases during acute infection, from mild, flu-like symptoms to severe and fatal encephalitis. A total of 20–50\% of patients who recovered from acute flavivirus infections experienced long-term cognitive issues. Here, we discuss these major neurotropic flaviviruses-induced clinical diseases in humans and the recent findings in animal models and provide insights into the underlying disease mechanisms.",

keywords = "animal models, flavivirus, neurological sequelae, neurotropic",

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volume = "14",

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T1 - Flaviviruses—Induced Neurological Sequelae

AU - Cody, Samantha Gabrielle

AU - Adam, Awadalkareem

AU - Siniavin, Andrei

AU - Kang, Sam S.

AU - Wang, Tian

PY - 2025/1

Y1 - 2025/1

N2 - Flaviviruses, a group of single-stranded RNA viruses spread by mosquitoes or ticks, include several significant neurotropic viruses, such as West Nile virus (WNV), Japanese encephalitis virus (JEV), tick-borne encephalitis virus (TBEV), and Zika virus (ZIKV). These viruses can cause a range of neurological diseases during acute infection, from mild, flu-like symptoms to severe and fatal encephalitis. A total of 20–50% of patients who recovered from acute flavivirus infections experienced long-term cognitive issues. Here, we discuss these major neurotropic flaviviruses-induced clinical diseases in humans and the recent findings in animal models and provide insights into the underlying disease mechanisms.

AB - Flaviviruses, a group of single-stranded RNA viruses spread by mosquitoes or ticks, include several significant neurotropic viruses, such as West Nile virus (WNV), Japanese encephalitis virus (JEV), tick-borne encephalitis virus (TBEV), and Zika virus (ZIKV). These viruses can cause a range of neurological diseases during acute infection, from mild, flu-like symptoms to severe and fatal encephalitis. A total of 20–50% of patients who recovered from acute flavivirus infections experienced long-term cognitive issues. Here, we discuss these major neurotropic flaviviruses-induced clinical diseases in humans and the recent findings in animal models and provide insights into the underlying disease mechanisms.

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KW - flavivirus

KW - neurological sequelae

KW - neurotropic

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JO - Pathogens

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Flaviviruses—Induced Neurological Sequelae

Abstract

Keywords

ASJC Scopus subject areas

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