Flow Diversion for Treatment of Intracranial Aneurysms in Pediatric Patients: Multicenter Case Series

Jacob Cherian, Visish Srinivasan, Michael T. Froehler, Jonathan A. Grossberg, C. Michael Cawley, Ricardo A. Hanel, Ajit Puri, Travis Dumont, Andrew F. Ducruet, Felipe Albuquerque, Adam Arthur, Ahmed Cheema, Alejandro Spiotta, Mohammad Anadani, Demetrius Lopes, Ahmed Saied, Louis Kim, Cory M. Kelly, Peng Roc Chen, J. MoccoReade De Leacy, Ciarán J. Powers, Ramesh Grandhi, Kyle M. Fargen, Stephen R. Chen, Jeremiah N. Johnson, Sandi Lam, Peter Kan

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


BACKGROUND: Though the Pipeline Embolization Device (Medtronic) is approved for use in adults 22 yr and older, the high efficacy and long-Term durability of the device is attractive for treatment of intracranial aneurysms in younger patients who often have aneurysms less amenable to traditional endovascular treatments. OBJECTIVE: To report technical, angiographic, and clinical outcomes in patients aged 21 or below undergoing flow-diversion treatment for intracranial aneurysms. METHODS: Retrospective review across 16 institutions identified 39 patients aged 21 or below undergoing 46 treatment sessions with Pipeline Embolization Device placement between 2012 and 2018. A total of 50 intracranial aneurysms were treated. Details regarding patient demographics, aneurysm characteristics, treatment considerations, clinical outcomes, and aneurysm occlusion were obtained and analyzed in a multicenter database. RESULTS: A total of 70% of patients were male. Nonsaccular morphology was seen in half of identified aneurysms. Six aneurysms were giant, and five patients were treated acutely after ruptured presentation. Eight patients were younger than 10 yr of age. Complete aneurysm occlusion was seen in 74% of treated aneurysms. Three aneurysms (6%) were retreated. A total of 83% of patients had a modified Rankin Scale scores of ≤2 at last clinical follow-up. There were 2 early mortalities (4.3%) in the immediate postprocedure period because of rerupture of a treated ruptured aneurysm. No recanalization of a previously occluded aneurysm was observed. CONCLUSION: Flow-diversion treatment is a safe and effective treatment for intracranial aneurysms in patients younger than 22 yr. Rates of complete aneurysm occlusion and adverse events are comparable for rates seen in older patients.

Original languageEnglish (US)
Pages (from-to)53-62
Number of pages10
Issue number1
StatePublished - Jul 1 2020
Externally publishedYes


  • Flow diversion
  • Intracranial aneurysm
  • Pediatric

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery


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