Fluconazole (UK-49,858) treatment of candidiasis in normal and diabetic rats

M. A. Fisher, P. Gregory Lee, W. F. Tarry

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    Fluconazole (UK-49,858), a new oral bistriazole antifungal agent, was compared with amphotericin B in the treatment of established systemic infection with Candida albicans in normal and diabetic rats. In normal rats, oral fluconazole at 10 mg/kg per day for 7 days reduced Candida colony counts in the kidneys and livers as well as amphotericin B did and was nearly as effective as amphotericin B in a 21-day treatment trial. There was no further reduction in Candida colony counts when normal rats were treated with fluconazole at 40 mg/kg twice a day for 7 days. In streptozotocin-induced diabetic rats, fluconazole at 20 mg/kg per day for either 7 or 21 days compared favorably with amphotericin B in efficacy. Results of our study suggest that oral fluconazole may be useful in the treatment of established disseminated candidiasis in normal as well as diabetic hosts.

    Original languageEnglish (US)
    Pages (from-to)1042-1045
    Number of pages4
    JournalAntimicrobial Agents and Chemotherapy
    Volume33
    Issue number7
    StatePublished - 1989

    Fingerprint

    Fluconazole
    Candidiasis
    Amphotericin B
    Candida
    Antifungal Agents
    Streptozocin
    Candida albicans
    Kidney
    Liver
    Infection

    ASJC Scopus subject areas

    • Pharmacology (medical)

    Cite this

    Fisher, M. A., Gregory Lee, P., & Tarry, W. F. (1989). Fluconazole (UK-49,858) treatment of candidiasis in normal and diabetic rats. Antimicrobial Agents and Chemotherapy, 33(7), 1042-1045.

    Fluconazole (UK-49,858) treatment of candidiasis in normal and diabetic rats. / Fisher, M. A.; Gregory Lee, P.; Tarry, W. F.

    In: Antimicrobial Agents and Chemotherapy, Vol. 33, No. 7, 1989, p. 1042-1045.

    Research output: Contribution to journalArticle

    Fisher, MA, Gregory Lee, P & Tarry, WF 1989, 'Fluconazole (UK-49,858) treatment of candidiasis in normal and diabetic rats', Antimicrobial Agents and Chemotherapy, vol. 33, no. 7, pp. 1042-1045.
    Fisher, M. A. ; Gregory Lee, P. ; Tarry, W. F. / Fluconazole (UK-49,858) treatment of candidiasis in normal and diabetic rats. In: Antimicrobial Agents and Chemotherapy. 1989 ; Vol. 33, No. 7. pp. 1042-1045.
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