Fluorescence probe for cervical examination during various reproductive states

Wenling S. Glassman, Qin Ping Liao, Shao Qing Shi, Linda Goodrum, Gayle Olson, Dora Martin, George Saade, Robert E. Garfield

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

These studies represent further investigations that have been done utilizing the fluorescence from pyridinoline, one of the major crosslinks of type I and III collagen, to evaluate cervical connective tissue changes during various female reproductive periods. Based on our previous studies, a prototype instrument has been constructed. The instrument was specifically designed for the purpose of vaginal examination of cervical connective tissue by measuring light induced fluorescence directly from the surface of the external os of the cervix. The studies were carried out on nonpregnant rats, rats during gestation at different periods, rats at different times during postpartum, and rats during preterm birth after being treated with antiprogesterone drugs. A study has also been done on humans during pregnancy and postpartum. The results parallel previous investigations that have used various invasive methods to analyze cervical extensibility, cervical collagen content and collagenase. In consideration of the important role of the collagen fibers and their turnover in the process of cervical function during pregnancy (softening or ripening at term), this method could be a useful tool for evaluating treatment strategies of the cervix. Moreover, the instrument could serve as a device for the non-invasive estimation of cervical status in the clinic and the diagnosis of the changes in the cervix during the preparation for labor.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
Pages286-292
Number of pages7
Volume2980
DOIs
StatePublished - 1997
EventAdvances in Fluorescence Sensing Technology III - San Jose, CA, United States
Duration: Feb 9 1997Feb 9 1997

Other

OtherAdvances in Fluorescence Sensing Technology III
CountryUnited States
CitySan Jose, CA
Period2/9/972/9/97

Fingerprint

Fluorescence
rats
Collagen
Rats
Probe
collagens
examination
connective tissue
fluorescence
probes
pregnancy
Pregnancy
Tissue
Collagen Type III
labor
Softening
Collagenases
Collagen Type I
softening
Preparation

Keywords

  • Cervix
  • Clinic examination
  • Collagen
  • Dilation
  • Fluorescence spectroscopy
  • Pregnancy
  • Pyridinoline

ASJC Scopus subject areas

  • Applied Mathematics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Cite this

Glassman, W. S., Liao, Q. P., Shi, S. Q., Goodrum, L., Olson, G., Martin, D., ... Garfield, R. E. (1997). Fluorescence probe for cervical examination during various reproductive states. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2980, pp. 286-292) https://doi.org/10.1117/12.273513

Fluorescence probe for cervical examination during various reproductive states. / Glassman, Wenling S.; Liao, Qin Ping; Shi, Shao Qing; Goodrum, Linda; Olson, Gayle; Martin, Dora; Saade, George; Garfield, Robert E.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2980 1997. p. 286-292.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Glassman, WS, Liao, QP, Shi, SQ, Goodrum, L, Olson, G, Martin, D, Saade, G & Garfield, RE 1997, Fluorescence probe for cervical examination during various reproductive states. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 2980, pp. 286-292, Advances in Fluorescence Sensing Technology III, San Jose, CA, United States, 2/9/97. https://doi.org/10.1117/12.273513
Glassman WS, Liao QP, Shi SQ, Goodrum L, Olson G, Martin D et al. Fluorescence probe for cervical examination during various reproductive states. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2980. 1997. p. 286-292 https://doi.org/10.1117/12.273513
Glassman, Wenling S. ; Liao, Qin Ping ; Shi, Shao Qing ; Goodrum, Linda ; Olson, Gayle ; Martin, Dora ; Saade, George ; Garfield, Robert E. / Fluorescence probe for cervical examination during various reproductive states. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2980 1997. pp. 286-292
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