Foamy histiocytes in the CSF of a patient with infantile Niemann-Pick disease

R. R. Chilcote, M. Miller, G. Dawson, Reuben Matalon

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Niemann-Pick disease is characterized by hepatosplenomegaly and progressive neurologic deterioration in the first year of life. Histiocytes of the reticuloendothelial system accumulate cytoplasmic inclusions, which results in characteristic 'foam cells'. In the examination of a patient with hepatosplenomegaly, discovery of these cells in bone marrow aspirates provides a valuable diagnostic clue. These cells, however, are few in number and may be difficult to recognize in standard preparations. We describe a case of Niemann-Pick disease in which foam cells were present in the spinal fluid and were easily demonstrated by cytocentrifugation. Evaluation of CSF cells by cytocentrifugation may provide a useful diagnostic tool in suspected cases of lipid storage disease.

Original languageEnglish (US)
Pages (from-to)76-77
Number of pages2
JournalAmerican Journal of Diseases of Children
Volume135
Issue number1
StatePublished - 1981
Externally publishedYes

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Niemann-Pick Diseases
Foam Cells
Histiocytes
Mononuclear Phagocyte System
Inclusion Bodies
Bone Marrow Cells
Nervous System
Lipids

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Foamy histiocytes in the CSF of a patient with infantile Niemann-Pick disease. / Chilcote, R. R.; Miller, M.; Dawson, G.; Matalon, Reuben.

In: American Journal of Diseases of Children, Vol. 135, No. 1, 1981, p. 76-77.

Research output: Contribution to journalArticle

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