Focused, wide-band, polymer-based optoacoustic transducers for noninvasive monitoring of total hemoglobin concentration and other blood variables

Emanuel Saerchen, Irene Petrov, Yuriy Petrov, Donald Prough, Walter Neu, Rinat Esenaliev

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

One of the most frequently performed blood tests, measurement of total hemoglobin concentration, requires invasive blood sampling. We developed an optoacoustic technique for noninvasive monitoring of total hemoglobin concentration and other blood variables by probing the radial artery or other blood vessels. Recently, we designed and built a focused, wide-band, polymer-based optoacoustic transducer for blood vessel probing with high, submillimeter lateral resolution and incorporated it into a highly portable, laser diode-based optoacoustic system. The focused optoacoustic transducer combines a fiber-optic delivery system and a wide-band piezosensor. First, we experimentally measured transducer parameters (lateral resolution, sensitivity, focal length). To test the transducer capabilities in measurement of total hemoglobin concentration and other blood parameters from blood vessels, we prepared a tissue phantom simulating strongly-scattering tissues with blood vessels of different diameters, spacing, and depths. Optoacoustic signals were acquired from blood at different hemoglobin concentration and oxygenation during transducer scanning over the phantom. In vivo experiments were performed from radial arteries and peripheral veins of different size, depth, and spacing. Submillimeter lateral resolution was obtained in the in vitro and in vivo experiments. The high resolution combined with the wide-band detection of the optoacoustic waves can be used for monitoring of blood variables in blood vessels with high accuracy, sensitivity, and specificity.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7899
DOIs
StatePublished - 2011
EventPhotons Plus Ultrasound: Imaging and Sensing 2011 - San Francisco, CA, United States
Duration: Jan 23 2011Jan 25 2011

Other

OtherPhotons Plus Ultrasound: Imaging and Sensing 2011
CountryUnited States
CitySan Francisco, CA
Period1/23/111/25/11

Fingerprint

Photoacoustic effect
Hemoglobin
hemoglobin
Transducers
blood vessels
Blood vessels
blood
Blood Vessels
Polymers
transducers
Hemoglobins
Blood
broadband
Monitoring
polymers
Radial Artery
Photoacoustic Techniques
arteries
Semiconductor Lasers
spacing

Keywords

  • Blood oxygenation
  • Noninvasive monitoring
  • Optoacoustics
  • Total hemoglobin concentration
  • Transducer

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Saerchen, E., Petrov, I., Petrov, Y., Prough, D., Neu, W., & Esenaliev, R. (2011). Focused, wide-band, polymer-based optoacoustic transducers for noninvasive monitoring of total hemoglobin concentration and other blood variables. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7899). [78994E] https://doi.org/10.1117/12.879490

Focused, wide-band, polymer-based optoacoustic transducers for noninvasive monitoring of total hemoglobin concentration and other blood variables. / Saerchen, Emanuel; Petrov, Irene; Petrov, Yuriy; Prough, Donald; Neu, Walter; Esenaliev, Rinat.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7899 2011. 78994E.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Saerchen, E, Petrov, I, Petrov, Y, Prough, D, Neu, W & Esenaliev, R 2011, Focused, wide-band, polymer-based optoacoustic transducers for noninvasive monitoring of total hemoglobin concentration and other blood variables. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 7899, 78994E, Photons Plus Ultrasound: Imaging and Sensing 2011, San Francisco, CA, United States, 1/23/11. https://doi.org/10.1117/12.879490
Saerchen, Emanuel ; Petrov, Irene ; Petrov, Yuriy ; Prough, Donald ; Neu, Walter ; Esenaliev, Rinat. / Focused, wide-band, polymer-based optoacoustic transducers for noninvasive monitoring of total hemoglobin concentration and other blood variables. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7899 2011.
@inproceedings{bdf5efcd870f4a098df121a7b9cf4b63,
title = "Focused, wide-band, polymer-based optoacoustic transducers for noninvasive monitoring of total hemoglobin concentration and other blood variables",
abstract = "One of the most frequently performed blood tests, measurement of total hemoglobin concentration, requires invasive blood sampling. We developed an optoacoustic technique for noninvasive monitoring of total hemoglobin concentration and other blood variables by probing the radial artery or other blood vessels. Recently, we designed and built a focused, wide-band, polymer-based optoacoustic transducer for blood vessel probing with high, submillimeter lateral resolution and incorporated it into a highly portable, laser diode-based optoacoustic system. The focused optoacoustic transducer combines a fiber-optic delivery system and a wide-band piezosensor. First, we experimentally measured transducer parameters (lateral resolution, sensitivity, focal length). To test the transducer capabilities in measurement of total hemoglobin concentration and other blood parameters from blood vessels, we prepared a tissue phantom simulating strongly-scattering tissues with blood vessels of different diameters, spacing, and depths. Optoacoustic signals were acquired from blood at different hemoglobin concentration and oxygenation during transducer scanning over the phantom. In vivo experiments were performed from radial arteries and peripheral veins of different size, depth, and spacing. Submillimeter lateral resolution was obtained in the in vitro and in vivo experiments. The high resolution combined with the wide-band detection of the optoacoustic waves can be used for monitoring of blood variables in blood vessels with high accuracy, sensitivity, and specificity.",
keywords = "Blood oxygenation, Noninvasive monitoring, Optoacoustics, Total hemoglobin concentration, Transducer",
author = "Emanuel Saerchen and Irene Petrov and Yuriy Petrov and Donald Prough and Walter Neu and Rinat Esenaliev",
year = "2011",
doi = "10.1117/12.879490",
language = "English (US)",
isbn = "9780819484369",
volume = "7899",
booktitle = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

}

TY - GEN

T1 - Focused, wide-band, polymer-based optoacoustic transducers for noninvasive monitoring of total hemoglobin concentration and other blood variables

AU - Saerchen, Emanuel

AU - Petrov, Irene

AU - Petrov, Yuriy

AU - Prough, Donald

AU - Neu, Walter

AU - Esenaliev, Rinat

PY - 2011

Y1 - 2011

N2 - One of the most frequently performed blood tests, measurement of total hemoglobin concentration, requires invasive blood sampling. We developed an optoacoustic technique for noninvasive monitoring of total hemoglobin concentration and other blood variables by probing the radial artery or other blood vessels. Recently, we designed and built a focused, wide-band, polymer-based optoacoustic transducer for blood vessel probing with high, submillimeter lateral resolution and incorporated it into a highly portable, laser diode-based optoacoustic system. The focused optoacoustic transducer combines a fiber-optic delivery system and a wide-band piezosensor. First, we experimentally measured transducer parameters (lateral resolution, sensitivity, focal length). To test the transducer capabilities in measurement of total hemoglobin concentration and other blood parameters from blood vessels, we prepared a tissue phantom simulating strongly-scattering tissues with blood vessels of different diameters, spacing, and depths. Optoacoustic signals were acquired from blood at different hemoglobin concentration and oxygenation during transducer scanning over the phantom. In vivo experiments were performed from radial arteries and peripheral veins of different size, depth, and spacing. Submillimeter lateral resolution was obtained in the in vitro and in vivo experiments. The high resolution combined with the wide-band detection of the optoacoustic waves can be used for monitoring of blood variables in blood vessels with high accuracy, sensitivity, and specificity.

AB - One of the most frequently performed blood tests, measurement of total hemoglobin concentration, requires invasive blood sampling. We developed an optoacoustic technique for noninvasive monitoring of total hemoglobin concentration and other blood variables by probing the radial artery or other blood vessels. Recently, we designed and built a focused, wide-band, polymer-based optoacoustic transducer for blood vessel probing with high, submillimeter lateral resolution and incorporated it into a highly portable, laser diode-based optoacoustic system. The focused optoacoustic transducer combines a fiber-optic delivery system and a wide-band piezosensor. First, we experimentally measured transducer parameters (lateral resolution, sensitivity, focal length). To test the transducer capabilities in measurement of total hemoglobin concentration and other blood parameters from blood vessels, we prepared a tissue phantom simulating strongly-scattering tissues with blood vessels of different diameters, spacing, and depths. Optoacoustic signals were acquired from blood at different hemoglobin concentration and oxygenation during transducer scanning over the phantom. In vivo experiments were performed from radial arteries and peripheral veins of different size, depth, and spacing. Submillimeter lateral resolution was obtained in the in vitro and in vivo experiments. The high resolution combined with the wide-band detection of the optoacoustic waves can be used for monitoring of blood variables in blood vessels with high accuracy, sensitivity, and specificity.

KW - Blood oxygenation

KW - Noninvasive monitoring

KW - Optoacoustics

KW - Total hemoglobin concentration

KW - Transducer

UR - http://www.scopus.com/inward/record.url?scp=79955492619&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955492619&partnerID=8YFLogxK

U2 - 10.1117/12.879490

DO - 10.1117/12.879490

M3 - Conference contribution

SN - 9780819484369

VL - 7899

BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

ER -