Force propagation across cells: mechanical coherence of dynamic cytoskeletons

Yunfei Cai, Michael Sheetz

Research output: Contribution to journalReview article

51 Citations (Scopus)

Abstract

A critical function of cells is to provide a force-bearing linkage from matrix to matrix, matrix to cells, or from cell to cell in a tissue and organ as well as a force generating structure. In fully differentiated skin cells, much of the force is borne by intermediate filaments. In dynamic tissues or isolated cells on matrix, high forces are generated by myosin II pulling on actin, either through stress fibers or through some other trans-cytoplasmic network. In epithelia, myosin II clearly plays a critical role in forming a contractile ring around wounds that provides turgor and restructuring forces. A major mystery is how a dynamic cytoskeleton can create a mechanically coherent cytoplasm. We suggest that the key lie in the continuous assembly of actin and myosin filaments in the cell periphery that has been recently found in isolated fibroblasts.

Original languageEnglish (US)
Pages (from-to)47-50
Number of pages4
JournalCurrent Opinion in Cell Biology
Volume21
Issue number1
DOIs
StatePublished - Feb 1 2009
Externally publishedYes

Fingerprint

Cytoskeleton
Myosin Type II
Stress Fibers
Intermediate Filaments
Myosins
Actin Cytoskeleton
Actins
Cytoplasm
Epithelium
Fibroblasts
Skin
Wounds and Injuries

ASJC Scopus subject areas

  • Cell Biology

Cite this

Force propagation across cells : mechanical coherence of dynamic cytoskeletons. / Cai, Yunfei; Sheetz, Michael.

In: Current Opinion in Cell Biology, Vol. 21, No. 1, 01.02.2009, p. 47-50.

Research output: Contribution to journalReview article

@article{44865dc1fa7943d6b771e5bbb6ae96fa,
title = "Force propagation across cells: mechanical coherence of dynamic cytoskeletons",
abstract = "A critical function of cells is to provide a force-bearing linkage from matrix to matrix, matrix to cells, or from cell to cell in a tissue and organ as well as a force generating structure. In fully differentiated skin cells, much of the force is borne by intermediate filaments. In dynamic tissues or isolated cells on matrix, high forces are generated by myosin II pulling on actin, either through stress fibers or through some other trans-cytoplasmic network. In epithelia, myosin II clearly plays a critical role in forming a contractile ring around wounds that provides turgor and restructuring forces. A major mystery is how a dynamic cytoskeleton can create a mechanically coherent cytoplasm. We suggest that the key lie in the continuous assembly of actin and myosin filaments in the cell periphery that has been recently found in isolated fibroblasts.",
author = "Yunfei Cai and Michael Sheetz",
year = "2009",
month = "2",
day = "1",
doi = "10.1016/j.ceb.2009.01.020",
language = "English (US)",
volume = "21",
pages = "47--50",
journal = "Current Opinion in Cell Biology",
issn = "0955-0674",
publisher = "Elsevier Limited",
number = "1",

}

TY - JOUR

T1 - Force propagation across cells

T2 - mechanical coherence of dynamic cytoskeletons

AU - Cai, Yunfei

AU - Sheetz, Michael

PY - 2009/2/1

Y1 - 2009/2/1

N2 - A critical function of cells is to provide a force-bearing linkage from matrix to matrix, matrix to cells, or from cell to cell in a tissue and organ as well as a force generating structure. In fully differentiated skin cells, much of the force is borne by intermediate filaments. In dynamic tissues or isolated cells on matrix, high forces are generated by myosin II pulling on actin, either through stress fibers or through some other trans-cytoplasmic network. In epithelia, myosin II clearly plays a critical role in forming a contractile ring around wounds that provides turgor and restructuring forces. A major mystery is how a dynamic cytoskeleton can create a mechanically coherent cytoplasm. We suggest that the key lie in the continuous assembly of actin and myosin filaments in the cell periphery that has been recently found in isolated fibroblasts.

AB - A critical function of cells is to provide a force-bearing linkage from matrix to matrix, matrix to cells, or from cell to cell in a tissue and organ as well as a force generating structure. In fully differentiated skin cells, much of the force is borne by intermediate filaments. In dynamic tissues or isolated cells on matrix, high forces are generated by myosin II pulling on actin, either through stress fibers or through some other trans-cytoplasmic network. In epithelia, myosin II clearly plays a critical role in forming a contractile ring around wounds that provides turgor and restructuring forces. A major mystery is how a dynamic cytoskeleton can create a mechanically coherent cytoplasm. We suggest that the key lie in the continuous assembly of actin and myosin filaments in the cell periphery that has been recently found in isolated fibroblasts.

UR - http://www.scopus.com/inward/record.url?scp=60749128399&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=60749128399&partnerID=8YFLogxK

U2 - 10.1016/j.ceb.2009.01.020

DO - 10.1016/j.ceb.2009.01.020

M3 - Review article

C2 - 19208463

AN - SCOPUS:60749128399

VL - 21

SP - 47

EP - 50

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

SN - 0955-0674

IS - 1

ER -