Forces on adhesive contacts affect cell function

Catherine G. Galbraith, Michael Sheetz

Research output: Contribution to journalArticle

228 Citations (Scopus)

Abstract

Cellular forces acting on the adhesive contacts made with the extracellular matrix (ECM) contribute significantly to cell shape, viability, signal transduction and motility. In the past two years, research has determined how cell spreading influences cell viability as well as cytoskeletal organization. The cytoskeleton generates a level of tension against the ECM that is proportional to ECM stiffness. The strength of this tension exerted against the ECM affects the migratory speed of the cell.

Original languageEnglish (US)
Pages (from-to)566-571
Number of pages6
JournalCurrent Opinion in Cell Biology
Volume10
Issue number5
DOIs
StatePublished - Jan 1 1998
Externally publishedYes

Fingerprint

Adhesives
Extracellular Matrix
Cell Survival
Cell Shape
Cytoskeleton
Signal Transduction
Research

ASJC Scopus subject areas

  • Cell Biology

Cite this

Forces on adhesive contacts affect cell function. / Galbraith, Catherine G.; Sheetz, Michael.

In: Current Opinion in Cell Biology, Vol. 10, No. 5, 01.01.1998, p. 566-571.

Research output: Contribution to journalArticle

Galbraith, Catherine G. ; Sheetz, Michael. / Forces on adhesive contacts affect cell function. In: Current Opinion in Cell Biology. 1998 ; Vol. 10, No. 5. pp. 566-571.
@article{0e076d3ac6a14ff184eaa961885466f3,
title = "Forces on adhesive contacts affect cell function",
abstract = "Cellular forces acting on the adhesive contacts made with the extracellular matrix (ECM) contribute significantly to cell shape, viability, signal transduction and motility. In the past two years, research has determined how cell spreading influences cell viability as well as cytoskeletal organization. The cytoskeleton generates a level of tension against the ECM that is proportional to ECM stiffness. The strength of this tension exerted against the ECM affects the migratory speed of the cell.",
author = "Galbraith, {Catherine G.} and Michael Sheetz",
year = "1998",
month = "1",
day = "1",
doi = "10.1016/S0955-0674(98)80030-6",
language = "English (US)",
volume = "10",
pages = "566--571",
journal = "Current Opinion in Cell Biology",
issn = "0955-0674",
publisher = "Elsevier Limited",
number = "5",

}

TY - JOUR

T1 - Forces on adhesive contacts affect cell function

AU - Galbraith, Catherine G.

AU - Sheetz, Michael

PY - 1998/1/1

Y1 - 1998/1/1

N2 - Cellular forces acting on the adhesive contacts made with the extracellular matrix (ECM) contribute significantly to cell shape, viability, signal transduction and motility. In the past two years, research has determined how cell spreading influences cell viability as well as cytoskeletal organization. The cytoskeleton generates a level of tension against the ECM that is proportional to ECM stiffness. The strength of this tension exerted against the ECM affects the migratory speed of the cell.

AB - Cellular forces acting on the adhesive contacts made with the extracellular matrix (ECM) contribute significantly to cell shape, viability, signal transduction and motility. In the past two years, research has determined how cell spreading influences cell viability as well as cytoskeletal organization. The cytoskeleton generates a level of tension against the ECM that is proportional to ECM stiffness. The strength of this tension exerted against the ECM affects the migratory speed of the cell.

UR - http://www.scopus.com/inward/record.url?scp=0031671026&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031671026&partnerID=8YFLogxK

U2 - 10.1016/S0955-0674(98)80030-6

DO - 10.1016/S0955-0674(98)80030-6

M3 - Article

C2 - 9818165

AN - SCOPUS:0031671026

VL - 10

SP - 566

EP - 571

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

SN - 0955-0674

IS - 5

ER -