Foregut carcinoids

A clinical and biochemical analysis

Paul M. Kirshbom, Aftab R. Kherani, Mark W. Onaitis, Ankie Hata, Theresa E. Kehoe, Carol Feldman, Jerome M. Feldman, Douglas Tyler

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background. Gastrointestinal foregut carcinoids make up a small percentage (3% to 6%) of all reported carcinoids. Because these tumors are so uncommon, comparisons between the subtypes have been difficult. The goal of this study was to compare the hormonal and clinical characteristics of gastric, duodenal, and pancreatic carcinoids. Methods. A prospective database of approximately 750 carcinoid patients seen by one author over 25 years was reviewed, and the 104 patients with gastric (33), duodenal (17), or pancreatic (54) carcinoids were selected as the subgroup for analysis. These patients were compared with regard to hormone levels, clinical course, treatment, and survival. Results. Duodenal carcinoids exhibited significantly lower serotoninergic hormone levels than did the gastric and pancreatic carcinoids (urine 5-hydroxyindoleacetic acid [mg/24 h], 5 ± 1 vs 16 ± 5 and 47 ± 12, respectively, P = .03). Pancreatic carcinoids presented with more advanced stage (distant metastases 87% vs 42% and 20% for gastric and duodenal, respectively) and had worse outcomes than patients with gastric and duodenal tumors with 10-year survivals of 10%, 59%, and 58%, respectively (P = .003). Conclusions. Pancreatic carcinoids produce higher levels of serotoninergic hormones and have a significantly higher stage and worse outcome than other foregut carcinoids. This study demonstrates that the organ of origin is an important determinant of hormonal activity and clinical course for patients with foregut carcinoids.

Original languageEnglish (US)
Pages (from-to)1105-1110
Number of pages6
JournalSurgery
Volume126
Issue number6
DOIs
StatePublished - 1999
Externally publishedYes

Fingerprint

Carcinoid Tumor
Stomach
Hormones
Hydroxyindoleacetic Acid
Survival
Neoplasms
Urine
Databases
Neoplasm Metastasis

ASJC Scopus subject areas

  • Surgery

Cite this

Kirshbom, P. M., Kherani, A. R., Onaitis, M. W., Hata, A., Kehoe, T. E., Feldman, C., ... Tyler, D. (1999). Foregut carcinoids: A clinical and biochemical analysis. Surgery, 126(6), 1105-1110. https://doi.org/10.1067/msy.2099.101430

Foregut carcinoids : A clinical and biochemical analysis. / Kirshbom, Paul M.; Kherani, Aftab R.; Onaitis, Mark W.; Hata, Ankie; Kehoe, Theresa E.; Feldman, Carol; Feldman, Jerome M.; Tyler, Douglas.

In: Surgery, Vol. 126, No. 6, 1999, p. 1105-1110.

Research output: Contribution to journalArticle

Kirshbom, PM, Kherani, AR, Onaitis, MW, Hata, A, Kehoe, TE, Feldman, C, Feldman, JM & Tyler, D 1999, 'Foregut carcinoids: A clinical and biochemical analysis', Surgery, vol. 126, no. 6, pp. 1105-1110. https://doi.org/10.1067/msy.2099.101430
Kirshbom PM, Kherani AR, Onaitis MW, Hata A, Kehoe TE, Feldman C et al. Foregut carcinoids: A clinical and biochemical analysis. Surgery. 1999;126(6):1105-1110. https://doi.org/10.1067/msy.2099.101430
Kirshbom, Paul M. ; Kherani, Aftab R. ; Onaitis, Mark W. ; Hata, Ankie ; Kehoe, Theresa E. ; Feldman, Carol ; Feldman, Jerome M. ; Tyler, Douglas. / Foregut carcinoids : A clinical and biochemical analysis. In: Surgery. 1999 ; Vol. 126, No. 6. pp. 1105-1110.
@article{25fd19e6bbe9445a9ecea1ea42d2381b,
title = "Foregut carcinoids: A clinical and biochemical analysis",
abstract = "Background. Gastrointestinal foregut carcinoids make up a small percentage (3{\%} to 6{\%}) of all reported carcinoids. Because these tumors are so uncommon, comparisons between the subtypes have been difficult. The goal of this study was to compare the hormonal and clinical characteristics of gastric, duodenal, and pancreatic carcinoids. Methods. A prospective database of approximately 750 carcinoid patients seen by one author over 25 years was reviewed, and the 104 patients with gastric (33), duodenal (17), or pancreatic (54) carcinoids were selected as the subgroup for analysis. These patients were compared with regard to hormone levels, clinical course, treatment, and survival. Results. Duodenal carcinoids exhibited significantly lower serotoninergic hormone levels than did the gastric and pancreatic carcinoids (urine 5-hydroxyindoleacetic acid [mg/24 h], 5 ± 1 vs 16 ± 5 and 47 ± 12, respectively, P = .03). Pancreatic carcinoids presented with more advanced stage (distant metastases 87{\%} vs 42{\%} and 20{\%} for gastric and duodenal, respectively) and had worse outcomes than patients with gastric and duodenal tumors with 10-year survivals of 10{\%}, 59{\%}, and 58{\%}, respectively (P = .003). Conclusions. Pancreatic carcinoids produce higher levels of serotoninergic hormones and have a significantly higher stage and worse outcome than other foregut carcinoids. This study demonstrates that the organ of origin is an important determinant of hormonal activity and clinical course for patients with foregut carcinoids.",
author = "Kirshbom, {Paul M.} and Kherani, {Aftab R.} and Onaitis, {Mark W.} and Ankie Hata and Kehoe, {Theresa E.} and Carol Feldman and Feldman, {Jerome M.} and Douglas Tyler",
year = "1999",
doi = "10.1067/msy.2099.101430",
language = "English (US)",
volume = "126",
pages = "1105--1110",
journal = "Surgery",
issn = "0039-6060",
publisher = "Mosby Inc.",
number = "6",

}

TY - JOUR

T1 - Foregut carcinoids

T2 - A clinical and biochemical analysis

AU - Kirshbom, Paul M.

AU - Kherani, Aftab R.

AU - Onaitis, Mark W.

AU - Hata, Ankie

AU - Kehoe, Theresa E.

AU - Feldman, Carol

AU - Feldman, Jerome M.

AU - Tyler, Douglas

PY - 1999

Y1 - 1999

N2 - Background. Gastrointestinal foregut carcinoids make up a small percentage (3% to 6%) of all reported carcinoids. Because these tumors are so uncommon, comparisons between the subtypes have been difficult. The goal of this study was to compare the hormonal and clinical characteristics of gastric, duodenal, and pancreatic carcinoids. Methods. A prospective database of approximately 750 carcinoid patients seen by one author over 25 years was reviewed, and the 104 patients with gastric (33), duodenal (17), or pancreatic (54) carcinoids were selected as the subgroup for analysis. These patients were compared with regard to hormone levels, clinical course, treatment, and survival. Results. Duodenal carcinoids exhibited significantly lower serotoninergic hormone levels than did the gastric and pancreatic carcinoids (urine 5-hydroxyindoleacetic acid [mg/24 h], 5 ± 1 vs 16 ± 5 and 47 ± 12, respectively, P = .03). Pancreatic carcinoids presented with more advanced stage (distant metastases 87% vs 42% and 20% for gastric and duodenal, respectively) and had worse outcomes than patients with gastric and duodenal tumors with 10-year survivals of 10%, 59%, and 58%, respectively (P = .003). Conclusions. Pancreatic carcinoids produce higher levels of serotoninergic hormones and have a significantly higher stage and worse outcome than other foregut carcinoids. This study demonstrates that the organ of origin is an important determinant of hormonal activity and clinical course for patients with foregut carcinoids.

AB - Background. Gastrointestinal foregut carcinoids make up a small percentage (3% to 6%) of all reported carcinoids. Because these tumors are so uncommon, comparisons between the subtypes have been difficult. The goal of this study was to compare the hormonal and clinical characteristics of gastric, duodenal, and pancreatic carcinoids. Methods. A prospective database of approximately 750 carcinoid patients seen by one author over 25 years was reviewed, and the 104 patients with gastric (33), duodenal (17), or pancreatic (54) carcinoids were selected as the subgroup for analysis. These patients were compared with regard to hormone levels, clinical course, treatment, and survival. Results. Duodenal carcinoids exhibited significantly lower serotoninergic hormone levels than did the gastric and pancreatic carcinoids (urine 5-hydroxyindoleacetic acid [mg/24 h], 5 ± 1 vs 16 ± 5 and 47 ± 12, respectively, P = .03). Pancreatic carcinoids presented with more advanced stage (distant metastases 87% vs 42% and 20% for gastric and duodenal, respectively) and had worse outcomes than patients with gastric and duodenal tumors with 10-year survivals of 10%, 59%, and 58%, respectively (P = .003). Conclusions. Pancreatic carcinoids produce higher levels of serotoninergic hormones and have a significantly higher stage and worse outcome than other foregut carcinoids. This study demonstrates that the organ of origin is an important determinant of hormonal activity and clinical course for patients with foregut carcinoids.

UR - http://www.scopus.com/inward/record.url?scp=0032732442&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032732442&partnerID=8YFLogxK

U2 - 10.1067/msy.2099.101430

DO - 10.1067/msy.2099.101430

M3 - Article

VL - 126

SP - 1105

EP - 1110

JO - Surgery

JF - Surgery

SN - 0039-6060

IS - 6

ER -