Formulation variables affecting release of diclofenac sodium from Eudragit-loaded microparticles

Mansi P. Shah, Pooja K. Patel, S. Lin, P. L. Madan

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Non-aqueous emulsification solvent evaporation method was used to prepare sustained release diclofenac sodium (DS) particles having high DS content while minimizing formulation time. Microparticles were evaluated on the basis of batch yield, encapsulation efficiency, particle size and particle size distribution, effect of surfactant concentration, phase volume ratio, different internal phases, and Eudragit RSPO or Eudragit RLPO used singly or in a 1:1 combination. The 1:1 combination of acetone and isopropanol as the internal phase produced microparticles with higher batch yield and higher encapsulation efficiency. A combination of 1: 1 Eudragit RSPO and Eudragit RLPO formed sustained release microparticles having higher encapsulation efficiency than microparticles formulated using individual polymers. The release of DS was faster from formulations prepared using 3% surfactant concentration than those prepared using 1% or 2% surfactant concentration. Formulations prepared using 60 ml and 80 ml external phase formed microparticles with higher encapsulation efficiency and slower DS release than those prepared using 100 ml external phase. With internal phase volume kept constant at 40 ml, the volume of external phase affected formulation time taking about 1.5 h when the external phase was 60 ml and about 3.5 h when the external phase volume was 100 ml.

Original languageEnglish (US)
Pages (from-to)241-250
Number of pages10
JournalAsian Journal of Pharmaceutical Sciences
Volume6
Issue number6
StatePublished - 2011
Externally publishedYes

Keywords

  • Diclofenac sodium
  • Emulsification solvent evaporation
  • Eudragit
  • Microparticles
  • Sustained release

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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