Fortilin

A Potential Target for the Prevention and Treatment of Human Diseases

Research output: Contribution to journalArticle

Abstract

Fortilin is a highly conserved 172-amino-acid polypeptide found in the cytosol, nucleus, mitochondria, extracellular space, and circulating blood. It is a multifunctional protein that protects cells against apoptosis, promotes cell growth and cell cycle progression, binds calcium (Ca2+) and has antipathogen activities. Its role in the pathogenesis of human and animal diseases is also diverse. Fortilin facilitates the development of atherosclerosis, contributes to both systemic and pulmonary arterial hypertension, participates in the development of cancers, and worsens diabetic nephropathy. It is important for the adaptive expansion of pancreatic β-cells in response to obesity and increased insulin requirement, for the regeneration of liver after hepatectomy, and for protection of the liver against alcohol- and ER stress-induced injury. Fortilin is a viable surrogate marker for in vivo apoptosis, and it plays a key role in embryo and organ development in vertebrates. In fish and shrimp, fortilin participates in host defense against bacterial and viral pathogens. Further translational research could prove fortilin to be a viable molecular target for treatment of various human diseases including and not limited to atherosclerosis, hypertension, certain tumors, diabetes mellitus, diabetic nephropathy, hepatic injury, and aberrant immunity and host defense.

Original languageEnglish (US)
JournalAdvances in Clinical Chemistry
DOIs
StateAccepted/In press - 2017

Fingerprint

Liver
Diabetic Nephropathies
Apoptosis
Mitochondria
Atherosclerosis
Cell growth
Pathogens
Medical problems
Fish
Tumors
Animal Diseases
Animals
Liver Regeneration
Blood
Translational Medical Research
Cells
Alcohols
Wounds and Injuries
Extracellular Space
Hepatectomy

Keywords

  • Alcohol liver injury
  • Apoptosis
  • Atherosclerosis
  • Cancers
  • Development
  • Diabetes mellitus
  • Endoplasmic reticulum (ER) stress
  • Fortilin
  • Histamine-releasing factor
  • Host defense
  • HRF
  • Hypertension
  • Immunity
  • IRE1α
  • Liver regeneration
  • Pulmonary arterial hypertension
  • TCTP
  • TPT1
  • Translationally controlled tumor protein
  • Tumors

ASJC Scopus subject areas

  • Chemistry(all)
  • Clinical Biochemistry

Cite this

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title = "Fortilin: A Potential Target for the Prevention and Treatment of Human Diseases",
abstract = "Fortilin is a highly conserved 172-amino-acid polypeptide found in the cytosol, nucleus, mitochondria, extracellular space, and circulating blood. It is a multifunctional protein that protects cells against apoptosis, promotes cell growth and cell cycle progression, binds calcium (Ca2+) and has antipathogen activities. Its role in the pathogenesis of human and animal diseases is also diverse. Fortilin facilitates the development of atherosclerosis, contributes to both systemic and pulmonary arterial hypertension, participates in the development of cancers, and worsens diabetic nephropathy. It is important for the adaptive expansion of pancreatic β-cells in response to obesity and increased insulin requirement, for the regeneration of liver after hepatectomy, and for protection of the liver against alcohol- and ER stress-induced injury. Fortilin is a viable surrogate marker for in vivo apoptosis, and it plays a key role in embryo and organ development in vertebrates. In fish and shrimp, fortilin participates in host defense against bacterial and viral pathogens. Further translational research could prove fortilin to be a viable molecular target for treatment of various human diseases including and not limited to atherosclerosis, hypertension, certain tumors, diabetes mellitus, diabetic nephropathy, hepatic injury, and aberrant immunity and host defense.",
keywords = "Alcohol liver injury, Apoptosis, Atherosclerosis, Cancers, Development, Diabetes mellitus, Endoplasmic reticulum (ER) stress, Fortilin, Histamine-releasing factor, Host defense, HRF, Hypertension, Immunity, IRE1α, Liver regeneration, Pulmonary arterial hypertension, TCTP, TPT1, Translationally controlled tumor protein, Tumors",
author = "Decha Pinkaew and Kenichi Fujise",
year = "2017",
doi = "10.1016/bs.acc.2017.06.006",
language = "English (US)",
journal = "Advances in Clinical Chemistry",
issn = "0065-2423",
publisher = "Academic Press Inc.",

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T2 - A Potential Target for the Prevention and Treatment of Human Diseases

AU - Pinkaew, Decha

AU - Fujise, Kenichi

PY - 2017

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N2 - Fortilin is a highly conserved 172-amino-acid polypeptide found in the cytosol, nucleus, mitochondria, extracellular space, and circulating blood. It is a multifunctional protein that protects cells against apoptosis, promotes cell growth and cell cycle progression, binds calcium (Ca2+) and has antipathogen activities. Its role in the pathogenesis of human and animal diseases is also diverse. Fortilin facilitates the development of atherosclerosis, contributes to both systemic and pulmonary arterial hypertension, participates in the development of cancers, and worsens diabetic nephropathy. It is important for the adaptive expansion of pancreatic β-cells in response to obesity and increased insulin requirement, for the regeneration of liver after hepatectomy, and for protection of the liver against alcohol- and ER stress-induced injury. Fortilin is a viable surrogate marker for in vivo apoptosis, and it plays a key role in embryo and organ development in vertebrates. In fish and shrimp, fortilin participates in host defense against bacterial and viral pathogens. Further translational research could prove fortilin to be a viable molecular target for treatment of various human diseases including and not limited to atherosclerosis, hypertension, certain tumors, diabetes mellitus, diabetic nephropathy, hepatic injury, and aberrant immunity and host defense.

AB - Fortilin is a highly conserved 172-amino-acid polypeptide found in the cytosol, nucleus, mitochondria, extracellular space, and circulating blood. It is a multifunctional protein that protects cells against apoptosis, promotes cell growth and cell cycle progression, binds calcium (Ca2+) and has antipathogen activities. Its role in the pathogenesis of human and animal diseases is also diverse. Fortilin facilitates the development of atherosclerosis, contributes to both systemic and pulmonary arterial hypertension, participates in the development of cancers, and worsens diabetic nephropathy. It is important for the adaptive expansion of pancreatic β-cells in response to obesity and increased insulin requirement, for the regeneration of liver after hepatectomy, and for protection of the liver against alcohol- and ER stress-induced injury. Fortilin is a viable surrogate marker for in vivo apoptosis, and it plays a key role in embryo and organ development in vertebrates. In fish and shrimp, fortilin participates in host defense against bacterial and viral pathogens. Further translational research could prove fortilin to be a viable molecular target for treatment of various human diseases including and not limited to atherosclerosis, hypertension, certain tumors, diabetes mellitus, diabetic nephropathy, hepatic injury, and aberrant immunity and host defense.

KW - Alcohol liver injury

KW - Apoptosis

KW - Atherosclerosis

KW - Cancers

KW - Development

KW - Diabetes mellitus

KW - Endoplasmic reticulum (ER) stress

KW - Fortilin

KW - Histamine-releasing factor

KW - Host defense

KW - HRF

KW - Hypertension

KW - Immunity

KW - IRE1α

KW - Liver regeneration

KW - Pulmonary arterial hypertension

KW - TCTP

KW - TPT1

KW - Translationally controlled tumor protein

KW - Tumors

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