Fourier transform infrared spectroscopy demonstrates the reactivity of the protonated carboxyl group of the acid salt of calcium bilirubinate

R. D. Soloway, J. G. Wu, D. F. Xu, Y. F. Zhang, D. K. Martini, N. K. Hong, R. S. Crowther

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Calcium bilirubinate is a major salt in pigment gallstones. Bilirubin IX (H2BR) is a tetrapyrrole with 1 propionic acid side chain on both the B and C rings. A striking feature is the strong intramolecular hydrogen bonding of both carboxyl groups as determined by x-ray diffraction. This greatly reduces aqueous solubility. Much less is known about the structure of the salts of calcium bilirubinate since single crystals have not been formed. One or both carboxyl groups of bilirubin may coordinate with calcium in stone, forming the acid or neutral salt.

Original languageEnglish (US)
Pages (from-to)262-263
Number of pages2
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume1145
DOIs
StatePublished - Dec 1 1989

Fingerprint

Infrared Spectroscopy
carboxyl group
Reactivity
Calcium
Bilirubin
Salt
Fourier transform infrared spectroscopy
calcium
Fourier transform
reactivity
Salts
infrared spectroscopy
salts
acids
Acids
Demonstrate
propionic acid
Propionic acid
Solubility
Tetrapyrroles

ASJC Scopus subject areas

  • Applied Mathematics
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Electrical and Electronic Engineering
  • Computer Science Applications

Cite this

Fourier transform infrared spectroscopy demonstrates the reactivity of the protonated carboxyl group of the acid salt of calcium bilirubinate. / Soloway, R. D.; Wu, J. G.; Xu, D. F.; Zhang, Y. F.; Martini, D. K.; Hong, N. K.; Crowther, R. S.

In: Proceedings of SPIE - The International Society for Optical Engineering, Vol. 1145, 01.12.1989, p. 262-263.

Research output: Contribution to journalArticle

Soloway, R. D. ; Wu, J. G. ; Xu, D. F. ; Zhang, Y. F. ; Martini, D. K. ; Hong, N. K. ; Crowther, R. S. / Fourier transform infrared spectroscopy demonstrates the reactivity of the protonated carboxyl group of the acid salt of calcium bilirubinate. In: Proceedings of SPIE - The International Society for Optical Engineering. 1989 ; Vol. 1145. pp. 262-263.
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