Fragment-based screening by protein crystallography: Successes and pitfalls

Keyphrases

• Fragment Screening 100%
• Protein Crystallography 100%
• Fragment-based Drug Discovery 66%
• X-ray Crystallography 33%
• Clinical Significance 33%
• Low Molecular Weight Compounds 33%
• High-throughput 33%
• Drug Target 33%
• Robotics 33%
• Screening Method 33%
• Diffraction Efficiency 33%
• Secretase 33%
• Heat Shock Protein 90 (Hsp90) 33%
• Phenylethanolamine N-methyltransferase 33%
• Fragment Library 33%
• Phosphodiesterase-4 (PDE4) 33%
• Synchrotron Radiation 33%
• Library Use 33%
• X-ray Data Collection 33%
• Library Design 33%

Medicine and Dentistry

• X-Ray Crystallography 100%
• Diffraction 100%
• Phosphodiesterase 100%
• Secretase 100%
• Synchrotron Radiation 100%
• Phenylethanolamine N Methyltransferase 100%

Pharmacology, Toxicology and Pharmaceutical Science

• Drug Discovery 100%
• Secretase 50%
• Phosphodiesterase 50%
• Synchrotron Radiation 50%
• Phenylethanolamine N Methyltransferase 50%