Free radical-dependent changes in constitutive nuclear factor kappa B in the aged hippocampus

Joel A. Kaufmann, Paula C. Bickford, Giulio Taglialatela

    Research output: Contribution to journalArticlepeer-review

    28 Scopus citations

    Abstract

    We have examined the levels of constitutively active NF-κB subunits p65, p50 and p52 in the hippocampus of aged (24 months) vs young (3 months) F344 rats. Although we found no significant age-dependent difference in baseline nuclear levels of any subunit, we did note a differential response to treatment with the antioxidant PBN. While PBN significantly reduced nuclear levels of all three subunits in aged rats, only p50 was significantly reduced in the nuclei of young animals. This shows that the impetus for constitutive NF-κB activity is different in young and aged animals and may reflect a state of chronic oxidative stress in the latter. In addition this suggests a dysregulation of NF-κB and may contribute to the inability of the aged CNS to cope with insults such as trauma and ischemia/reperfusion.

    Original languageEnglish (US)
    Pages (from-to)1917-1920
    Number of pages4
    JournalNeuroReport
    Volume13
    Issue number15
    DOIs
    StatePublished - Oct 28 2002

    Keywords

    • Aging
    • CNS
    • Hippocampus
    • Nuclear factor kappa B
    • Oxidative stress
    • PBN

    ASJC Scopus subject areas

    • Neuroscience(all)

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