Free radical-dependent changes in constitutive nuclear factor kappa B in the aged hippocampus

Joel A. Kaufmann, Paula C. Bickford, Giulio Taglialatela

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

We have examined the levels of constitutively active NF-κB subunits p65, p50 and p52 in the hippocampus of aged (24 months) vs young (3 months) F344 rats. Although we found no significant age-dependent difference in baseline nuclear levels of any subunit, we did note a differential response to treatment with the antioxidant PBN. While PBN significantly reduced nuclear levels of all three subunits in aged rats, only p50 was significantly reduced in the nuclei of young animals. This shows that the impetus for constitutive NF-κB activity is different in young and aged animals and may reflect a state of chronic oxidative stress in the latter. In addition this suggests a dysregulation of NF-κB and may contribute to the inability of the aged CNS to cope with insults such as trauma and ischemia/reperfusion.

Original languageEnglish (US)
Pages (from-to)1917-1920
Number of pages4
JournalNeuroReport
Volume13
Issue number15
StatePublished - Oct 28 2002

Fingerprint

NF-kappa B
Free Radicals
Hippocampus
Inbred F344 Rats
Reperfusion
Oxidative Stress
Ischemia
Antioxidants
Wounds and Injuries
rat Ruvbl1 protein

Keywords

  • Aging
  • CNS
  • Hippocampus
  • Nuclear factor kappa B
  • Oxidative stress
  • PBN

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Free radical-dependent changes in constitutive nuclear factor kappa B in the aged hippocampus. / Kaufmann, Joel A.; Bickford, Paula C.; Taglialatela, Giulio.

In: NeuroReport, Vol. 13, No. 15, 28.10.2002, p. 1917-1920.

Research output: Contribution to journalArticle

Kaufmann, Joel A. ; Bickford, Paula C. ; Taglialatela, Giulio. / Free radical-dependent changes in constitutive nuclear factor kappa B in the aged hippocampus. In: NeuroReport. 2002 ; Vol. 13, No. 15. pp. 1917-1920.
@article{1875bb793db3437681ff27ae3e3cc64c,
title = "Free radical-dependent changes in constitutive nuclear factor kappa B in the aged hippocampus",
abstract = "We have examined the levels of constitutively active NF-κB subunits p65, p50 and p52 in the hippocampus of aged (24 months) vs young (3 months) F344 rats. Although we found no significant age-dependent difference in baseline nuclear levels of any subunit, we did note a differential response to treatment with the antioxidant PBN. While PBN significantly reduced nuclear levels of all three subunits in aged rats, only p50 was significantly reduced in the nuclei of young animals. This shows that the impetus for constitutive NF-κB activity is different in young and aged animals and may reflect a state of chronic oxidative stress in the latter. In addition this suggests a dysregulation of NF-κB and may contribute to the inability of the aged CNS to cope with insults such as trauma and ischemia/reperfusion.",
keywords = "Aging, CNS, Hippocampus, Nuclear factor kappa B, Oxidative stress, PBN",
author = "Kaufmann, {Joel A.} and Bickford, {Paula C.} and Giulio Taglialatela",
year = "2002",
month = "10",
day = "28",
language = "English (US)",
volume = "13",
pages = "1917--1920",
journal = "NeuroReport",
issn = "0959-4965",
publisher = "Lippincott Williams and Wilkins",
number = "15",

}

TY - JOUR

T1 - Free radical-dependent changes in constitutive nuclear factor kappa B in the aged hippocampus

AU - Kaufmann, Joel A.

AU - Bickford, Paula C.

AU - Taglialatela, Giulio

PY - 2002/10/28

Y1 - 2002/10/28

N2 - We have examined the levels of constitutively active NF-κB subunits p65, p50 and p52 in the hippocampus of aged (24 months) vs young (3 months) F344 rats. Although we found no significant age-dependent difference in baseline nuclear levels of any subunit, we did note a differential response to treatment with the antioxidant PBN. While PBN significantly reduced nuclear levels of all three subunits in aged rats, only p50 was significantly reduced in the nuclei of young animals. This shows that the impetus for constitutive NF-κB activity is different in young and aged animals and may reflect a state of chronic oxidative stress in the latter. In addition this suggests a dysregulation of NF-κB and may contribute to the inability of the aged CNS to cope with insults such as trauma and ischemia/reperfusion.

AB - We have examined the levels of constitutively active NF-κB subunits p65, p50 and p52 in the hippocampus of aged (24 months) vs young (3 months) F344 rats. Although we found no significant age-dependent difference in baseline nuclear levels of any subunit, we did note a differential response to treatment with the antioxidant PBN. While PBN significantly reduced nuclear levels of all three subunits in aged rats, only p50 was significantly reduced in the nuclei of young animals. This shows that the impetus for constitutive NF-κB activity is different in young and aged animals and may reflect a state of chronic oxidative stress in the latter. In addition this suggests a dysregulation of NF-κB and may contribute to the inability of the aged CNS to cope with insults such as trauma and ischemia/reperfusion.

KW - Aging

KW - CNS

KW - Hippocampus

KW - Nuclear factor kappa B

KW - Oxidative stress

KW - PBN

UR - http://www.scopus.com/inward/record.url?scp=0037191375&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037191375&partnerID=8YFLogxK

M3 - Article

VL - 13

SP - 1917

EP - 1920

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

IS - 15

ER -