Frequency of nonsentinel lymph node metastasis in melanoma

Kelly M. McMasters, Sandra L. Wong, Michael J. Edwards, Celia Chao, Merrick I. Ross, R. Dirk Noyes, Vicki Viar, Patricia B. Cerrito, Douglas S. Reintgen

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

Background: Completion lymph node dissection (CLND) may not be necessary for some patients because nodal metastasis is rarely detected beyond the sentinel lymph nodes (SLNs). This analysis was performed to determine, among patients with positive SLNs, the rate of nodal metastasis found in nonsentinel nodes (NSNs). Methods: This analysis includes patients with positive sentinel nodes, detected by hematoxylin and eosin (H&E) staining or immunohistochemistry (IHC), who then underwent CLND. Results: This analysis included 274 patients with at least one positive SLN who underwent CLND of 282 involved regional nodal basins. Of the 282 SLN-positive nodal basins, 45 (16%) were found to have positive NSNs in the CLND specimen. Breslow thickness, Clark level, presence of ulceration, histological subtype, presence of vertical growth phase, evidence of regression, presence of lymphovascular invasion, number of positive SLNs, age, sex, and presence of multiple draining nodal basins were not predictive of positive nodes in the CLND specimen. Patients with SLN metastases detected only by IHC had an equal likelihood of having positive NSNs as those patients with positive SLNs on H&E examination. Conclusions: No patient population could be identified with minimal risk of non-SLN metastasis. When a positive SLN is identified on either H&E staining or IHC, CLND should be performed routinely.

Original languageEnglish (US)
Pages (from-to)137-141
Number of pages5
JournalAnnals of Surgical Oncology
Volume9
Issue number2
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Melanoma
Lymph Node Excision
Lymph Nodes
Neoplasm Metastasis
Immunohistochemistry
Staining and Labeling
Sentinel Lymph Node
Hematoxylin
Eosine Yellowish-(YS)
Growth
Population

Keywords

  • Lymph node dissection
  • Lymphatic mapping
  • Melanoma
  • Nonsentinel node
  • Sentinel lymph node

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

McMasters, K. M., Wong, S. L., Edwards, M. J., Chao, C., Ross, M. I., Noyes, R. D., ... Reintgen, D. S. (2002). Frequency of nonsentinel lymph node metastasis in melanoma. Annals of Surgical Oncology, 9(2), 137-141. https://doi.org/10.1245/aso.2002.9.2.137

Frequency of nonsentinel lymph node metastasis in melanoma. / McMasters, Kelly M.; Wong, Sandra L.; Edwards, Michael J.; Chao, Celia; Ross, Merrick I.; Noyes, R. Dirk; Viar, Vicki; Cerrito, Patricia B.; Reintgen, Douglas S.

In: Annals of Surgical Oncology, Vol. 9, No. 2, 2002, p. 137-141.

Research output: Contribution to journalArticle

McMasters, KM, Wong, SL, Edwards, MJ, Chao, C, Ross, MI, Noyes, RD, Viar, V, Cerrito, PB & Reintgen, DS 2002, 'Frequency of nonsentinel lymph node metastasis in melanoma', Annals of Surgical Oncology, vol. 9, no. 2, pp. 137-141. https://doi.org/10.1245/aso.2002.9.2.137
McMasters, Kelly M. ; Wong, Sandra L. ; Edwards, Michael J. ; Chao, Celia ; Ross, Merrick I. ; Noyes, R. Dirk ; Viar, Vicki ; Cerrito, Patricia B. ; Reintgen, Douglas S. / Frequency of nonsentinel lymph node metastasis in melanoma. In: Annals of Surgical Oncology. 2002 ; Vol. 9, No. 2. pp. 137-141.
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